2,3,5,6-四氟吡啶合成路线 （共 61 条）
反应条件
1.1: 88 percent / hydrazine monohydrate / ethanol / 2 h / Heating 2.1: 65 percent / aq. CuSO4 / Heating 3.1: 68 percent / hydrazine monohydrate / ethanol / 6 h / Heating 4.1: 79 percent / aq. CuSO4 / Heating 5.1: BuLi / tetrahydrofuran; hexane 5.2: 73 percent / hexachloroethane / tetrahydrofuran; hexane 6.1: 51 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 6 h / 150 °C View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
ammonia T=60°C; 5 h;
参考文献
Vaganova; Kusov; Rodionov; Shundrina; Malykhin
Russian Chemical Bulletin, 2007 , vol. 56, # 11 p. 2239 - 2246
反应条件
ammonia T=120°C; 35 h;
参考文献
Vaganova; Kusov; Rodionov; Shundrina; Malykhin
Russian Chemical Bulletin, 2007 , vol. 56, # 11 p. 2239 - 2246
反应条件
1.1: 88 percent / hydrazine monohydrate / ethanol / 2 h / Heating 2.1: 65 percent / aq. CuSO4 / Heating 3.1: BuLi / tetrahydrofuran; hexane / 2 h / -75 °C 3.2: 78 percent / Br2 / 1 h / -75 °C 4.1: 70 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 2 h / 150 °C View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1: 2,3,5,6-tetrafluoropyridine With n-butyllithium in diethyl ether; pentane T=-60°C; 1 h; 2: chloro-trimethyl-silane in diethyl ether; pentane T=-40 - 20°C;
参考文献
Tyrra, Wieland; Aboulkacem, Said; Pantenburg, Ingo
Journal of Organometallic Chemistry, 2006 , vol. 691, # 3 p. 514 - 522
反应条件
ammonia T=150°C; 67 h; Autoclave;
参考文献
Kusov, Soltan Z.; Rodionov, Vladimir I.; Vaganova, Tamara A.; Shundrina, Inna K.; Malykhin, Evgenij V.
Journal of Fluorine Chemistry, 2009 , vol. 130, # 5 p. 461 - 465
反应条件
ammonia T=120°C; 35 h;
参考文献
Vaganova; Kusov; Rodionov; Shundrina; Malykhin
Russian Chemical Bulletin, 2007 , vol. 56, # 11 p. 2239 - 2246
反应条件
1: With n-butyllithium in diethyl ether; hexane
T=-78°C; 1 h;
2: With iodine cloride in diethyl ether; hexane
T=-40°C; 2 h; Further stages.;
参考文献
Abo-Amer, Anwar; Frohn, Hermann-Josef; Steinberg, Christoph; Westphal, Ulrich
Journal of Fluorine Chemistry, 2006 , vol. 127, # 10 SPEC. ISS. p. 1311 - 1323
反应条件
1.1: 88 percent / hydrazine monohydrate / ethanol / 2 h / Heating
2.1: 65 percent / aq. CuSO4 / Heating
3.1: BuLi / tetrahydrofuran; hexane / 2 h / -75 °C
3.2: 78 percent / Br2 / 1 h / -75 °C
View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
hydrazine hydrate in ethanol
2 h; Heating;
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
