2-(1-甲基乙基)-苯并呋喃合成路线 （共 23 条）
反应条件
1: 2-iodophenol With N,N,N',N'-tetramethylguanidine; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=20°C; 1 h; Inert atmosphere;
2: N,N-dimethylmethylacetylene in N,N-dimethyl-formamide
T=20°C; 48 h;
参考文献
MERCK SHARP and DOHME CORP.; NAIR, Anilkumar, G.; KOZLOWSKI, Joseph, A.; DUCA, Jose, S.; ROSENBLUM, Stuart, B.
Patent: WO2012/125662 A1, 2012 ;
Location in patent: Page/Page column 41 ;
WO 2012/125662 A1
反应条件
triethylamine in toluene
12 h; Heating / reflux;
参考文献
KALYPSYS, INC.
Patent: WO2009/29625 A1, 2009 ;
Location in patent: Page/Page column 63 ;
WO 2009/029625 A1
反应条件
hydrogen bromide in acetic acid
T=100°C; 0.5 h;
参考文献
David, M.; Sauleau, J.; Sauleau, A.
Tetrahedron, 1988 , vol. 44, # 12 p. 3587 - 3594
反应条件
1: 2,3-benzofuran With tert.-butyl lithium in tetrahydrofuran; hexane
T=-78°C; 2 h; Inert atmosphere;
2: 2-iodo-propane in tetrahydrofuran; hexane
T=-78 - 20°C; Inert atmosphere;
参考文献
Ortega, Nuria; Urban, Slawomir; Beiring, Bernhard; Glorius, Frank
Angewandte Chemie - International Edition, 2012 , vol. 51, # 7 p. 1710 - 1713
反应条件
1: RuHCl(CO)(PPh3)3 / anhydrous xylene / 20 °C / Reflux; Inert atmosphere
2: Grubb's 2nd generation catalyst / anhydrous xylene; toluene / 2 h / 80 °C / Inert atmosphere
View Scheme
参考文献
Kobayashi, Takaaki; Arisawa, Mitsuhiro; Shuto, Satoshi
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 4 p. 1219 - 1224
反应条件
1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2: RuHCl(CO)(PPh3)3 / anhydrous xylene / 20 °C / Reflux; Inert atmosphere
3: Grubb's 2nd generation catalyst / anhydrous xylene; toluene / 2 h / 80 °C / Inert atmosphere
View Scheme
参考文献
Kobayashi, Takaaki; Arisawa, Mitsuhiro; Shuto, Satoshi
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 4 p. 1219 - 1224
反应条件
1: 71 percent / bromine / CCl4 / Heating; Irradiation
2: 94 percent / toluene / 4 h / Heating
3: 97 percent / 48 percent HBr / H2O / 3 h / Heating
4: 80 percent / pyridine / CHCl3 / 3 h / Heating
5: 80 percent / triethylamine / toluene / 3 h / Heating
View Scheme
参考文献
Hercouet, A.; Corre, M. Le
Tetrahedron, 1981 , vol. 37, # 16 p. 2867 - 2874
反应条件
1: 83 percent / HBr / acetonitrile / 2 h / 100 °C
2: 80 percent / pyridine / CHCl3 / 3 h / Heating
3: 80 percent / triethylamine / toluene / 3 h / Heating
View Scheme
参考文献
Hercouet, A.; Corre, M. Le
Tetrahedron, 1981 , vol. 37, # 16 p. 2867 - 2874
反应条件
1: 94 percent / toluene / 4 h / Heating
2: 97 percent / 48 percent HBr / H2O / 3 h / Heating
3: 80 percent / pyridine / CHCl3 / 3 h / Heating
4: 80 percent / triethylamine / toluene / 3 h / Heating
View Scheme
参考文献
Hercouet, A.; Corre, M. Le
Tetrahedron, 1981 , vol. 37, # 16 p. 2867 - 2874
反应条件
1: 80 percent / pyridine / CHCl3 / 3 h / Heating
2: 80 percent / triethylamine / toluene / 3 h / Heating
View Scheme
参考文献
Hercouet, A.; Corre, M. Le
Tetrahedron, 1981 , vol. 37, # 16 p. 2867 - 2874
