3-(甲基硫代)-5-苯基-1,2,4-三嗪合成路线 （共 16 条）
反应条件
sodium hydrogencarbonate in ethanol; water 2 h; Reflux; regioselective reaction;
参考文献
Lv, Wei; Banerjee, Biplab; Molland, Katrina L.; Seleem, Mohamed N.; Ghafoor, Adil; Hamed, Maha I.; Wan, Baojie; Franzblau, Scott G.; Mesecar, Andrew D.; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 406 - 418
反应条件
sodium hydrogencarbonate in ethanol 1 h; Heating;
参考文献
Pitts, William J; Guo, Junqing; Dhar, T G Murali; Shen, Zhongqi; Gu, Henry H; Watterson, Scott H; Bednarz, Mark S; Chen, Bang Chi; Barrish, Joel C; Bassolino, Donna; Cheney, Daniel; Fleener, Catherine A; Rouleau, Katherine A; Hollenbaugh, Diane L; Iwanowicz, Edwin J
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 16 p. 2137 - 2140
反应条件
sodium hydroxide; potassium hexacyanoferrate(III)
参考文献
Konno, Shoetsu; Sagi, Mataichi; Yoshida, Nobuko; Yamanaka, Hiroshi
Heterocycles, 1987 , vol. 26, # 12 p. 3111 - 3114
反应条件
1: tetrahydrofuran / 5 h / -78 - 20 °C 2: DDQ / toluene / 24 h / 20 °C View Scheme
参考文献
Alphonse, France-Aimee; Suzenet, Franck; Keromnes, Anne; Lebret, Bruno; Guillaumet, Gerald
Synthesis, 2004 , # 17 p. 2893 - 2899
反应条件
1: selenium(IV) oxide / 1,4-dioxane; water / 5 h / |Reflux 2: sodium hydrogencarbonate / water; ethanol / 2 h / |Reflux View Scheme
参考文献
Lv, Wei; Banerjee, Biplab; Molland, Katrina L.; Seleem, Mohamed N.; Ghafoor, Adil; Hamed, Maha I.; Wan, Baojie; Franzblau, Scott G.; Mesecar, Andrew D.; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 406 - 418
反应条件
1: 71 percent / 80percent m-chloroperbenzoic acid / CH2Cl2 / 3 h / Ambient temperature 2: 1.) NaH / 1) THF, 0 deg C, 2) THF, RT, 1 h 3: 95 percent / chlorobenzene / 16.5 h / Heating 4: 63 percent Turnov. / 2,3-dicloro-5,6-dicyano-1,4-benzoquinone / dioxane / 6 h / Heating View Scheme
参考文献
Taylor, Edward C.; Macor, John E.
Tetrahedron Letters, 1986 , vol. 27, # 4 p. 431 - 432
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 8 h / -20 - -15 °C 2: iron nitrate (III); ammonia / tetrahydrofuran / -33 °C 3: N-bromosuccinmide / N,N-dimethyl-formamide / -25 °C 4: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.25 h / 150 °C / Inert atmosphere View Scheme
参考文献
HEPTARES THERAPEUTICS LIMITED; CONGREVE, Miles Stuart; ANDREWS, Stephen Philippe; MASON, Jonathan Stephen; RICHARDSON, Christine Mary; BROWN, Giles Albert
Patent: WO2011/95625 A1, 2011 ;
WO 2011/095625 A1
反应条件
1: tetrahydrofuran / Ambient temperature 2: 1.) NaBH4, 2.) KMnO4 View Scheme
参考文献
Konno, Shoetsu; Sagi, Mataichi; Yoshida, Nobuko; Yamanaka, Hiroshi
Heterocycles, 1987 , vol. 26, # 12 p. 3111 - 3114
参考文献
Diamond Shamrock Corporation
Patent: US4157392 A1, 1979 ;
反应条件
in methanol 10 h; Heating;
参考文献
Heilman; Scozzie; Wayner; Gullo; Ariyan
Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 3 p. 282 - 287
