(R)-(-)-3-羟基十四烷酸合成路线 （共 32 条）
反应条件
1: With hydrogen; (R)-1,1'-bis(diphenylphosphino)-2,2'-binapthyl; ruthenium trichloride in methanol T=40 - 50°C; P=3361.46 Torr; 20 h; 2: With lithium hydroxide in tetrahydrofuran; water
参考文献
Bazin, Helene G.; Bess, Laura S.; Livesay, Mark T.; Ryter, Kendal T.; Johnson, Craig L.; Arnold, Jeffrey S.; Johnson, David A.
Tetrahedron Letters, 2006 , vol. 47, # 13 p. 2087 - 2092
反应条件
lithium hydroxide in methanol; water 12 h;
参考文献
Bauer, Joerg; Brandenburg, Klaus; Zaehringer, Ulrich; Rademann, Joerg
Chemistry - A European Journal, 2006 , vol. 12, # 27 p. 7116 - 7124
反应条件
hydrogenchloride in dichloromethane T=100°C; Hydrolysis; 12 h;
参考文献
Nandanan; Phukan, Prodeep; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 8 p. 893 - 896
反应条件
hydrogenchloride; sodium hydroxide in methanol; water
参考文献
Hoffmann-La Roche Inc.
Patent: US5245056 A1, 1993 ;
反应条件
potassium hydroxide in ethanol
参考文献
Huang, Guangfei; Hollingsworth, Rawle I.
Tetrahedron Asymmetry, 1998 , vol. 9, # 23 p. 4113 - 4115
反应条件
2: di-t-butyl-p-cresol / tetrahydrofuran / 3 h / 65 °C / Pseudomonas lipase View Scheme
参考文献
Bauer, Joerg; Brandenburg, Klaus; Zaehringer, Ulrich; Rademann, Joerg
Chemistry - A European Journal, 2006 , vol. 12, # 27 p. 7116 - 7124
反应条件
potassium dihydrogenphosphate; baker's yeast; D-glucose in water T=28°C; 48 h; Yield given. Yields of byproduct given;
参考文献
Utaka, Masanori; Watabu, Hisashi; Higashi, Hiroshi; Sakai, Takashi; Tsuboi, Sadao; Torii, Sigeru
Journal of Organic Chemistry, 1990 , vol. 55, p. 3917 - 3921
反应条件
(S)-1-methyl-2-phenylethylamine
参考文献
Sugai, Takeshi; Ritzen, Helena; Wong, Chi-Huey
Tetrahedron: Asymmetry, 1993 , vol. 4, # 5 p. 1051 - 1058
反应条件
1: methanol / 5 h / Heating 2: 1.) H2, AcOH, 2.) NaOH / 1.) (R,R)-tartaric acid-NaBr-Raney nickel ((R,R)-TA-NaBr-MRNi) / 1.) C2H5COOCH3, 100 deg C, 100 kg/cm2 View Scheme
参考文献
Nakahata, Masaaki; Imaida, Motomasa; Ozaki, Hiroshi; Harada, Tadao; Tai, Akira
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 7 p. 2186 - 2189
反应条件
Porcine Pancreas Lipase; water in aq. phosphate buffer T=36°C; pH=7.6; 7 h; enantioselective reaction;
参考文献
Kuecuek, Hatice Baspinar; Yusufoglu, Ayse
Monatshefte fur Chemie, 2013 , vol. 144, # 7 p. 1087 - 1091
