1: With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate in acetone T=20 - 75°C; Baker-VenKataraman transformation; 12 h; 2: With potassium hydroxide in ethanol 0.333333 h; Heating; Further stages.;

sulfuric acid

potassium carbonate; acetone

Hydrolysis;

1: 96 percent / 1,4-diazabicyclo<2.2.2>octane / dimethylformamide / 2 h / Ambient temperature 2: 92 percent / various solvent(s) / 1 h / Heating 3: 86 percent / Raney nickel / ethanol / 1 h / Ambient temperature View Scheme