2,5-双(氯甲基)噻吩合成路线 （共 10 条）
反应条件
1: formaldehyd With hydrogenchloride in water T=60°C; 2: thiophene in water T=25 - 30°C; 0.333333 h;
参考文献
CIBA HOLDING INC.
Patent: WO2008/101806 A2, 2008 ;
Location in patent: Page/Page column 31-33 ;
反应条件
phosphoric acid in acetic acid 15 h; Ambient temperature;
参考文献
Takeshita, Michinori; Tashiro, Masashi
Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2837 - 2845
参考文献
Hojjatie, Massoud; Muralidharan, Subramaniam; Freiser, Henry
Tetrahedron, 1989 , vol. 45, # 6 p. 1611 - 1622
Title/Abstract Full Text View citing articles Show Details
Jen, Kwan-Yue; Jow, Richard; Shacklette, L. W.; Maxfield, M.; Eckhardt, Helmut; Elsenbaumer, Ronald L.
Molecular Crystals and Liquid Crystals (1969-1991), 1988 , vol. 160, p. 69 - 78
反应条件
thionyl chloride in dichloromethane Yield given;
参考文献
Gomez; Segura; Martin
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7501 - 7511
反应条件
2: SOCl2 View Scheme
参考文献
Garrigues, Bernard
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 53, # 1-4 p. 75 - 79
反应条件
potassium hydroxide; potassium permanganate
参考文献
Birkinshaw; Chaplen
Biochemical Journal, 1955 , vol. 60, p. 255,259
反应条件
1: acetone; potassium permanganate
2: diethyl ether
View Scheme
参考文献
Griffing; Salisbury
Journal of the American Chemical Society, 1948 , vol. 70, p. 3416,3418
反应条件
1: acetic acid
2: sodium ethylate; ethanol
View Scheme
参考文献
Griffing; Salisbury
Journal of the American Chemical Society, 1948 , vol. 70, p. 3416,3418
反应条件
sodium in ethanol
12 h; Heating;
参考文献
Lucas, C. Robert; Shuang, Liu; Newlands, Michael J.; Charland, Jean-Pierre; Gabe, Eric J.
Canadian Journal of Chemistry, 1988 , vol. 66, p. 1506 - 1512
反应条件
1: aqueous KOH-solution; potassium permanganate
2: benzene; pyridine; thionyl chloride
View Scheme
参考文献
Griffing; Salisbury
Journal of the American Chemical Society, 1948 , vol. 70, p. 3416,3418
