water T=150°C; 1 h; also 2,3-dihydro-3,5-dihydroxy-6(13C)methyl-4(H)-pyran-4-one; var. temp., pH, and time; effect of 2,4-dihydroxy-2,5-dimethyl-3(2H)-furanone;

[3H]-L-Alanine T=50°C; pH=7.4; 48 h; aq. phosphate bufferin air;

water T=150°C; 1 h; also 2,3-dihydro-3,5-dihydroxy-6(13C)methyl-4(H)-pyran-4-one; var. temp., pH, and time; effect of 2,4-dihydroxy-2,5-dimethyl-3(2H)-furanone;

water T=150°C; 1 h; also 2,3-dihydro-3,5-dihydroxy-6(13C)methyl-4(H)-pyran-4-one; var. temp., pH, and time; effect of 2,4-dihydroxy-2,5-dimethyl-3(2H)-furanone;

water T=150°C; 1 h; also 2,3-dihydro-3,5-dihydroxy-6(13C)methyl-4(H)-pyran-4-one; var. temp., pH, and time; effect of 2,4-dihydroxy-2,5-dimethyl-3(2H)-furanone;

water T=150°C; 1 h; also 2,3-dihydro-3,5-dihydroxy-6(13C)methyl-4(H)-pyran-4-one; var. temp., pH, and time; effect of 2,4-dihydroxy-2,5-dimethyl-3(2H)-furanone;

water T=150°C; 1 h; also 2,3-dihydro-3,5-dihydroxy-6(13C)methyl-4(H)-pyran-4-one; var. temp., pH, and time; effect of 2,4-dihydroxy-2,5-dimethyl-3(2H)-furanone;

Stage #1: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102438', constants.ctx, '0')">piperidine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '506007', constants.ctx, '0')">acetic acid</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a> <br />T=20 - 70&deg;C;&nbsp;<br />Stage #2: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '506166', constants.ctx, '0')">mercaptoacetic acid</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a> <br />T=75&deg;C;&nbsp;20.6667&nbsp;h;&nbsp;<br /> <br /> &nbsp;

Stage #1: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102438', constants.ctx, '0')">piperidine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a> <br />Condensation;&nbsp;2&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br />Stage #2: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '506166', constants.ctx, '0')">mercaptoacetic acid</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1718733', constants.ctx, '0')">ethanol</a> <br />Elimination;&nbsp;24&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;&nbsp;Title compound not separated from byproducts;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102438', constants.ctx, '0')">piperidine</a> <br />&nbsp;1.) C₂H₅OH, reflux, 1.5 h, 2.) C₂H₅OH, 90 deg C, 22 h;&nbsp;&nbsp;Yield given. Multistep reaction;&nbsp;<br /> &nbsp;