2-(2-氧代丙基)苯甲酸合成路线 （共 20 条）
反应条件
1: With sodium hydroxide; ethanol; water T=80°C; 5 h; 2: With hydrogenchloride in water
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US2005/182045 A1, 2005 ;
Location in patent: Page/Page column 52 ;
US 20050182045 A1
反应条件
hydrogenchloride; titanium(III) chloride; ammonium acetate; sodium methylate in methanol; water 1.5 h; Ambient temperature;
参考文献
Hauser, Frank M.; Baghdanov, Vaceli M.
Journal of Organic Chemistry, 1988 , vol. 53, # 20 p. 4676 - 4681
反应条件
1: 2-iodo benzoic acid With N,N-diethyl-N-isopropylamine; di-n-butyltin dihydride in benzene T=40°C; 12 h; 2: acetylacetone With sodium carbonate in methanol; water T=85 - 90°C; 24 h;
参考文献
Sarma; Maitra
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 11 p. 1148 - 1150
反应条件
1: 86 percent / triethylamine / dimethylsulfoxide / Ambient temperature 2: 77 percent / NaBH4 / dimethylsulfoxide / 1 h / Ambient temperature 3: 72 percent / NaOCH3, TiCl3, CH3CO2NH4, 6 N HCl / methanol; H2O / 1.5 h / Ambient temperature View Scheme
参考文献
Hauser, Frank M.; Baghdanov, Vaceli M.
Journal of Organic Chemistry, 1988 , vol. 53, # 20 p. 4676 - 4681
反应条件
1: 77 percent / NaBH4 / dimethylsulfoxide / 1 h / Ambient temperature 2: 72 percent / NaOCH3, TiCl3, CH3CO2NH4, 6 N HCl / methanol; H2O / 1.5 h / Ambient temperature View Scheme
参考文献
Hauser, Frank M.; Baghdanov, Vaceli M.
Journal of Organic Chemistry, 1988 , vol. 53, # 20 p. 4676 - 4681
反应条件
potassium tert-butylate in ammonia Irradiation;
参考文献
Bunnett,J.F.; Sundberg,J.E.
Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, p. 2620 - 2628
反应条件
1: NaBH4 / methanol 2: SOCl2 / 3 h / 50 - 60 °C 3: diethyl ether 4: HCl 5: Zn/HOAc View Scheme
参考文献
Bhatt, M. Vivekananda; El Ashry, Shaker H.; Somayaji, Vishwanatha
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 6 p. 473 - 486
反应条件
1: diethyl ether 2: HCl 3: Zn/HOAc View Scheme
参考文献
Bhatt, M. Vivekananda; El Ashry, Shaker H.; Somayaji, Vishwanatha
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 6 p. 473 - 486
反应条件
1: SOCl2 / 3 h / 50 - 60 °C 2: diethyl ether 3: HCl 4: Zn/HOAc View Scheme
参考文献
Bhatt, M. Vivekananda; El Ashry, Shaker H.; Somayaji, Vishwanatha
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 6 p. 473 - 486
参考文献
Salway; Kipping
Journal of the Chemical Society, 1909 , vol. 95, p. 170
