1H-苯并咪唑-2-甲酸合成路线 （共 30 条）
反应条件
Irradiationreaction in acidic CH3OH/H2O at pH 3.0; Product distributionMechanismQuantum yield;
参考文献
Herrmann, Christiane; Foerster, Rolf; Koch, Helmut; Wamhoff, Heinrich
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 10 p. 1431 - 1437
参考文献
Dellweg et al.
Biochemische Zeitschrift, 1956 , vol. 327, p. 422,447
参考文献
Bistrzycki; Przeworski
Chemische Berichte, 1912 , vol. 45, p. 3495
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C; Esterification; methylation; 3 h;
参考文献
Orjales, Aurelio; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro; Tapia, Ines; Mosquera, Ramon; Labeaga, Luis
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 5 p. 415 - 422
反应条件
thionyl chloride 1 h; Reflux;
参考文献
Harisha, Reddy S.; Hosamani, Kallappa M.; Keri, Rangappa S.
Archiv der Pharmazie, 2009 , vol. 342, # 7 p. 412 - 419
参考文献
Bistrzycki; Przeworski
Chemische Berichte, 1912 , vol. 45, p. 3495
反应条件
sulfuric acid; nitric acid
参考文献
Borza, Istvan; Kolok, Sandor; Gere, Aniko; Nagy, Jozsef; Fodor, Laszlo; Galgoczy, Kornel; Fetter, Jozsef; Bertha, Ferenc; Agai, Bela; Horvath, Csilla; Farkas, Sandor; Domany, Gyoergy
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4638 - 4640
反应条件
thionyl chloride Heating / reflux;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2006/49681 A2, 2006 ;
Location in patent: Page/Page column 40 ;
WO 2006/049681 A2
反应条件
PPA
T=180 - 190°C; Condensation; 3 h;
参考文献
Ramaiah; Grossert; Hooper; Dubey; Ramanatham
Journal of the Indian Chemical Society, 1999 , vol. 76, # 3 p. 140 - 144
反应条件
1: thionyl chloride / |Reflux
2: hydrazine hydrate / methanol
View Scheme
参考文献
Zheng, Jinyun; Yu, Yujian; Zhen, Xiaomin; Yang, Erbing; Zhao, Yufen
Phosphorus, Sulfur and Silicon and the Related Elements, 2013 , vol. 188, # 11 p. 1564 - 1575
