反-4-氧-2-戊烯酸甲酯合成路线 （共 16 条）
反应条件
triethylamine in N,N-dimethyl-formamide 12 h; Ambient temperature;
参考文献
Oren, Jakob; Demuth, Martin; Fuchs, Benzion
Synthesis, 1987 , # 9 p. 850 - 853
反应条件
ruthenium in dichloromethane
3 h; Heating;
参考文献
Choi; Choon Woo Lee; Chatterjee; Grubbs
Journal of the American Chemical Society, 2001 , vol. 123, # 42 p. 10417 - 10418
反应条件
1: With bromine in chloroform
T=20°C;
2: With diisopropylamine in chloroform
1 h;
参考文献
Mamaghani, Manouchehr; Alizadehnia, Alireza
Journal of Chemical Research - Part S, 2002 , # 8 p. 386 - 387
反应条件
in N,N-dimethyl-formamide
T=0 - 5°C; 0.5 - 0.583333 h;
参考文献
BIOSYNTH AB
Patent: WO2006/48236 A1, 2006 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: 10 percent / active MnO2 / NaCN / acetic acid / 5 h
2: 3.3 percent / 60 percent aqueous HClO4 / 20 h / Heating
View Scheme
参考文献
Cardellach, J.; Estopa, C.; Font, J.; Moreno-Manas, M.; Ortuno, R. M.; et al.
Tetrahedron, 1982 , vol. 38, # 15 p. 2377 - 2394
反应条件
in benzene
42 h; Heating;
参考文献
Schuda, Paul Francis; Ebner, Cynthia B.; Potlock, Steven J.
Synthesis, 1987 , # 12 p. 1055 - 1057
反应条件
bromine; triethylamine
1) -78 deg C, 10 min, dichloromethane, 2) -78 deg C to room temp.; Yield given. Multistep reaction;
参考文献
Boehm, Ingrid; Schulz, Rick; Reissig, Hans-Ulrich
Tetrahedron Letters, 1982 , vol. 23, # 19 p. 2013 - 2016
反应条件
1: NBS, potassium carbonate / acetone; H2O / 0.5 h / 25 °C
2: triethylamine / diethyl ether / 24 h / Ambient temperature
View Scheme
参考文献
Kulinkovich, O. G.; Tischenko, I. G.; Romashin, J. N.; Savitskaya, L. N.
Synthesis, 1986 , # 5 p. 378 - 379
反应条件
1: diethyl ether
2: (i) MeOH, (ii) aq. AcOH
View Scheme
参考文献
Verhe,R. et al.
Journal of Organic Chemistry, 1977 , vol. 42, # 7 p. 1256 - 1258
反应条件
perchloric acid
20 h; Heating; Further byproducts given;
参考文献
Cardellach, J.; Estopa, C.; Font, J.; Moreno-Manas, M.; Ortuno, R. M.; et al.
Tetrahedron, 1982 , vol. 38, # 15 p. 2377 - 2394
