1-甲基-4-亚甲基环己烷合成路线 （共 24 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol Ambient temperature;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 71 - 76
反应条件
T=20°C; Hydrogenation;
参考文献
Adv. Catalysis, , vol. 9, p. 15,18
反应条件
hydrogen; palladium on activated charcoal in ethanol Ambient temperature;
参考文献
Ishiyama, Jun-ichi; Senda, Yasuhisa; Imaizumi, Shin
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1982 , p. 71 - 76
反应条件
T=20°C; Hydrogenation;
参考文献
Siegel; Dunkel
Adv. Catalysis, 1957 , vol. 9, p. 15,18
反应条件
n-butyllithium; potassium 2-methyl-2-butoxide 1) hexane, 16 h, r.t.; 6 h, reflux, 2) hexane, -78 deg C; r.t., 20 h; Yield given. Multistep reaction;
参考文献
Wilhelm, Dieter; Clark, Timothy; Friedl, Thomas; Schleyer, Paul von Rague
Chemische Berichte, 1983 , vol. 116, # 2 p. 751 - 760
反应条件
n-butyllithium; potassium 2-methyl-2-butoxide 1) r.t., 16 h, 2) reflux, 6 h; further reagent: D2O; Mechanism;
参考文献
Wilhelm, Dieter; Clark, Timothy; Friedl, Thomas; Schleyer, Paul von Rague
Chemische Berichte, 1983 , vol. 116, # 2 p. 751 - 760
反应条件
1: 88 percent / H2 / Raney nickel / ethanol / 48 h / 100 °C / 76000 Torr
2: 92 percent / Na2Cr2O7, H2SO4 / diethyl ether; H2O / 3 h
3: 1) NaH / 1) DMSO, 2 h, 80 deg C, 2) DMSO, 2 h, 50 deg C
4: 92 percent / LiAlH4 / diethyl ether / 2 h / Heating
5: 95 percent / pyridine / 24 h / Ambient temperature
6: 72 percent / LiBr / tetrahydrofuran / 36 h / Heating
7: Bu3SnH / 1 h / Irradiation
View Scheme
参考文献
Della, Ernest W.; Knill, Andrew M.; Pigou, Paul E.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2110 - 2114
反应条件
1: 92 percent / Na2Cr2O7, H2SO4 / diethyl ether; H2O / 3 h
2: 1) NaH / 1) DMSO, 2 h, 80 deg C, 2) DMSO, 2 h, 50 deg C
3: 92 percent / LiAlH4 / diethyl ether / 2 h / Heating
4: 95 percent / pyridine / 24 h / Ambient temperature
5: 72 percent / LiBr / tetrahydrofuran / 36 h / Heating
6: Bu3SnH / 1 h / Irradiation
View Scheme
参考文献
Della, Ernest W.; Knill, Andrew M.; Pigou, Paul E.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2110 - 2114
反应条件
1: 95 percent / pyridine / 24 h / Ambient temperature
2: 72 percent / LiBr / tetrahydrofuran / 36 h / Heating
3: Bu3SnH / 1 h / Irradiation
View Scheme
参考文献
Della, Ernest W.; Knill, Andrew M.; Pigou, Paul E.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2110 - 2114
反应条件
1: 1) NaH / 1) DMSO, 2 h, 80 deg C, 2) DMSO, 2 h, 50 deg C
2: 92 percent / LiAlH4 / diethyl ether / 2 h / Heating
3: 95 percent / pyridine / 24 h / Ambient temperature
4: 72 percent / LiBr / tetrahydrofuran / 36 h / Heating
5: Bu3SnH / 1 h / Irradiation
View Scheme
参考文献
Della, Ernest W.; Knill, Andrew M.; Pigou, Paul E.
Journal of Organic Chemistry, 1993 , vol. 58, # 8 p. 2110 - 2114
