4-羟基噻吩并[3,2-C]吡啶合成路线 （共 13 条）
反应条件
tributyl-amine; triethylamine in diphenylether; water; acetone
参考文献
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Patent: US5731315 A1, 1998 ;
US 5731315 A
反应条件
copper in quinoline T=200 - 210°C; 2 h;
参考文献
Farnier,M. et al.
Canadian Journal of Chemistry, 1976 , vol. 54, p. 1066 - 1073
反应条件
copper in quinoline T=200 - 210°C; 1 h;
参考文献
Farnier,M. et al.
Canadian Journal of Chemistry, 1976 , vol. 54, p. 1066 - 1073
反应条件
1: With triethylamine in acetone Cooling with ice; 2: With sodium azide in water; acetone 1 h; Cooling with ice; 3: With tributyl-amine; diphenylamine T=220°C; 1.5 h;
参考文献
Asagarasu, Akira; Matsui, Teruaki; Hayashi, Hiroyuki; Tamaoki, Satoru; Yamauchi, Yukinao; Sato, Michitaka
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 1 p. 34 - 42
反应条件
1: xylene / 2 h / Heating 2: aq. HBr / 0.75 h / Heating 3: Cu / quinoline / 2 h / 200 - 210 °C View Scheme
参考文献
Farnier,M. et al.
Canadian Journal of Chemistry, 1976 , vol. 54, p. 1066 - 1073
反应条件
1: aq. HBr / 0.75 h / Heating 2: Cu / quinoline / 2 h / 200 - 210 °C View Scheme
参考文献
Farnier,M. et al.
Canadian Journal of Chemistry, 1976 , vol. 54, p. 1066 - 1073
反应条件
in diphenylether; dichloromethane 1 h; Heating; Yield given;
参考文献
New, James S.; Christopher, William L.; Yevich, Joseph P.; Butler, Rhett; Schlemmer, R. Francis; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1147 - 1156
反应条件
1: xylene / 2 h / Heating 2: aq. KOH / 4 h / Heating 3: Cu / quinoline / 2 h / 200 - 210 °C View Scheme
参考文献
Farnier,M. et al.
Canadian Journal of Chemistry, 1976 , vol. 54, p. 1066 - 1073
反应条件
1: aq. KOH / 4 h / Heating 2: Cu / quinoline / 2 h / 200 - 210 °C View Scheme
参考文献
Farnier,M. et al.
Canadian Journal of Chemistry, 1976 , vol. 54, p. 1066 - 1073
反应条件
ammonium acetate T=155°C; Substitution; 72 h;
参考文献
Rewinkel; Lucas; Smit; Noach; Van Dinther; Rood; Jenneboer; Van Boeckel
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 19 p. 2837 - 2842
