5-苯基-6-乙基-2,4-二氨基嘧啶合成路线 （共 9 条）
反应条件
sodium ethanolate in ethanol T=130°C; 8 h;
参考文献
Holsworth, Daniel D.; Stier, Michael; Edmunds, Jeremy J.; He, Wei; Place, Samuel; Maiti, Samarendra
Synthetic Communications, 2003 , vol. 33, # 20 p. 3467 - 3475
反应条件
1: 86 percent / sodium hydride / tetrahydrofuran / 21 h / 0 - 85 °C 2: conc. H2SO4; molecular sieves / 18 h / 180 - 200 °C 3: 45 percent / NaOEt / ethanol / 8 h / 130 °C View Scheme
参考文献
THE HOSPITAL FOR SICK CHILDREN
Patent: US2011/195985 A1, 2011 ;
反应条件
1: conc. H2SO4; molecular sieves / 18 h / 180 - 200 °C 2: 45 percent / NaOEt / ethanol / 8 h / 130 °C View Scheme
参考文献
Logemann et al.
Chemische Berichte, 1954 , vol. 87, p. 435,439
Chemische Berichte, 1954 , vol. 87, p. 1175,1178
反应条件
diethyl ether anschliessenden Erwaermen mit Guanidin in Aethanol;
参考文献
Russell; Hitchings
Journal of the American Chemical Society, 1951 , vol. 73, p. 3763,3766
反应条件
in dimethyl sulfoxide T=80°C; 0.0833333 h;
参考文献
Tarnchompoo, Bongkoch; Sirichaiwat, Chawanee; Phupong, Worrapong; Intaraudom, Chakapong; Sirawaraporn, Worachart; Kamchonwongpaisan, Sumalee; Vanichtanankul, Jarunee; Thebtaranonth, Yodhathai; Yuthavong, Yongyuth
Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1244 - 1252
参考文献
THE HOSPITAL FOR SICK CHILDREN
Patent: US2011/195985 A1, 2011 ;
Location in patent: Page/Page column 14; 15 ;
反应条件
ethanol anschliessenden Erhitzen mit Guanidin in Aethanol;
参考文献
Logemann et al.
Chemische Berichte, 1954 , vol. 87, p. 435,439
Chemische Berichte, 1954 , vol. 87, p. 1175,1178
反应条件
sulfuric acid; nitric acid
T=0 - 20°C; 2 h;
参考文献
Holsworth, Daniel D.; Stier, Michael; Edmunds, Jeremy J.; He, Wei; Place, Samuel; Maiti, Samarendra
Synthetic Communications, 2003 , vol. 33, # 20 p. 3467 - 3475
反应条件
1: 51 percent / conc. H2SO4; conc. HNO3 / 2 h / 0 - 20 °C
2: 98 percent / H2 / Raney nickel / methanol; tetrahydrofuran / 18 h / 2585.74 Torr
View Scheme
参考文献
Holsworth, Daniel D.; Stier, Michael; Edmunds, Jeremy J.; He, Wei; Place, Samuel; Maiti, Samarendra
Synthetic Communications, 2003 , vol. 33, # 20 p. 3467 - 3475
