咪唑并[1,2-a]吡啶合成路线 （共 42 条）
反应条件
1: 1.) water, 2.) HClO4 / 1.) MeOH, 50 deg C, 2 h 2: 72 percent / aq. NaOH / methanol / 2 h / Heating View Scheme
参考文献
Galons, Herve; Bergerat, Isabelle; Combet Farnoux, Claude; Miocque, Marcel
Synthesis, 1982 , # 12 p. 1103 - 1105
反应条件
T=200 - 210°C; im Rohr;
参考文献
Gueiffier, Alain; Lhassani, Mohammed; Elhakmaoui, Ahmed; Snoeck, Robert; Andrei, Graciela; Chavignon, Olivier; Teulade, Jean-Claude; Kerbal, Abdelali; Essassi, El Mokhtar; Debouzy, Jean-Claude; Witvrouw, Myriam; Blache, Yves; Balzarini, Jan; De Clercq, Erik; Chapat, Jean-Pierre
Journal of Medicinal Chemistry, 1996 , vol. 39, # 14 p. 2856 - 2859
反应条件
1: 79 percent / ethanol / 6 h / Heating 2: 90 percent / fuming nitric acid, conc. sulphuric acid 3: hydrazine hydrate / ethanol / 0.5 h / Heating; various solvents and reaction conditions View Scheme
参考文献
Rees, Charles W.; Smith, David I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1159 - 1164
反应条件
1: 90 percent / fuming nitric acid, conc. sulphuric acid 2: hydrazine hydrate / ethanol / 0.5 h / Heating; various solvents and reaction conditions View Scheme
参考文献
Rees, Charles W.; Smith, David I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1159 - 1164
反应条件
1: 1.7 g / aq. HCl / H2O / 0.25 h / Heating 2: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 3: 4 h / 250 - 270 °C View Scheme
参考文献
Parrick, John; Wilcox, Russel; Kelly, Anthony H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 132 - 135
参考文献
Parrick, John; Wilcox, Russel; Kelly, Anthony H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 132 - 135
反应条件
hydrazine hydrate in ethanol 12 h; Heating;
参考文献
Rees, Charles W.; Smith, David I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1159 - 1164
反应条件
1: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 2: 4 h / 250 - 270 °C View Scheme
参考文献
Parrick, John; Wilcox, Russel; Kelly, Anthony H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 132 - 135
反应条件
1: 1.) aq. HCl, 2.) aq. sodium nitrite / 1.) 50 deg C, 1 h, 2.) 30 min, reflux 2: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 3: 4 h / 250 - 270 °C View Scheme
参考文献
Parrick, John; Wilcox, Russel; Kelly, Anthony H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 132 - 135
反应条件
T=150 - 160°C; im Rohr;
参考文献
Tschitschibabin
Chemische Berichte, 1925 , vol. 58, p. 1706
Chemische Berichte, 1926 , vol. 59, p. 2048
