咪唑并[1,2-a]吡啶合成路线 （共 42 条）
反应条件
sodium hydrogencarbonate in ethanol 2 h; Heating;
参考文献
Loeber, Stefan; Huebner, Harald; Gmeiner, Peter
Bioorganic & Medicinal Chemistry Letters, 1999 , vol. 9, # 1 p. 97 - 102
参考文献
G. D. Searle and Co.
Patent: US4721718 A1, 1988 ;
反应条件
C46H48N6O5Pd; potassium acetate in N,N-dimethyl acetamide T=160°C; 24 h; Inert atmosphere;
参考文献
Nandi, Debkumar; Jhou, Yang-Ming; Lee, Jhen-Yi; Kuo, Bing-Chiuan; Liu, Chien-Yu; Huang, Pei-Wen; Lee, Hon Man
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9384 - 9390
反应条件
anhydrous sodium hydrogen carbonate; sodium chloride in ethylene glycol dimethyl ether; dichloromethane; water
参考文献
Laboratoire Innothera
Patent: US5981544 A1, 1999 ;
参考文献
Laboratoire Innothera
Patent: US5981544 A1, 1999 ;
反应条件
in methanol; glycerol
参考文献
Laboratoire Innothera
Patent: US5981544 A1, 1999 ;
参考文献
The Regents of the University of Michigan
Patent: US6214801 B1, 2001 ;
反应条件
sodium carbonate in 1,4-dioxane; water Cyclization; Tschitschibabin reaction; 22 h; Heating;
参考文献
Tomoda, Haruhiko; Hirano, Takafumi; Saito, Shojiro; Mutai, Toshiki; Araki, Koji
Bulletin of the Chemical Society of Japan, 1999 , vol. 72, # 6 p. 1327 - 1334
反应条件
1: 3.8 g / 0.08 h / 130 °C 2: 1.) aq. sodium hydroxide, 2.) aq. HCl / 1.) reflux, 3 - 4 h, 2.) heating, 10 min 3: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 4: 4 h / 250 - 270 °C View Scheme
参考文献
Parrick, John; Wilcox, Russel; Kelly, Anthony H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 132 - 135
反应条件
1: 1.) aq. sodium hydroxide, 2.) aq. HCl / 1.) reflux, 3 - 4 h, 2.) heating, 10 min 2: 0.9 g / sodium acetate, acetic anhydride / 0.5 h / Heating 3: 4 h / 250 - 270 °C View Scheme
参考文献
Parrick, John; Wilcox, Russel; Kelly, Anthony H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 132 - 135
