吡唑并[1,5-a]吡啶合成路线 （共 14 条）
反应条件
1: With sulfuric acid; water 2.25 h; Reflux; 2: With sodium hydroxide in water
参考文献
Bethel, Paul A.; Campbell, Andrew D.; Goldberg, Frederick W.; Kemmitt, Paul D.; Lamont, Gillian M.; Suleman, Abid
Tetrahedron, 2012 , vol. 68, # 27-28 p. 5434 - 5444
反应条件
mono(bis(di-tert-butyl(4-(dimethylamino)phenyl)phosphonio)palladium(II))dichloride; water; sodium carbonate in ethylene glycol dimethyl ether T=85°C; Suzuki coupling; 3 h; Inert atmosphere;
参考文献
Bethel, Paul A.; Campbell, Andrew D.; Goldberg, Frederick W.; Kemmitt, Paul D.; Lamont, Gillian M.; Suleman, Abid
Tetrahedron, 2012 , vol. 68, # 27-28 p. 5434 - 5444
参考文献
Anderson, Paul L.; Hasak, James P; Kahle, Alicia D.; Paolella, Nicholas A.; Shapiro, Michael J.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1149 - 1152
反应条件
potassium carbonate in N,N-dimethyl-formamide 6 h; Ambient temperature;
参考文献
Tsuchiya, Takashi; Sashida, Haruki; Konoshita, Ari
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4568 - 4572
反应条件
triethylamine in ethanol 6 h; Heating;
参考文献
Tominaga, Yoshinori; Ichihara, Yuichi; Hosomi, Akira
Heterocycles, 1988 , vol. 27, # 10 p. 2345 - 2348
反应条件
1: isopropylmagnesium chloride lithium chloride complex / tetrahydrofuran / 2 h / 5 - 10 °C / Inert atmosphere 2: mono(bis(di-tert-butyl(4-(dimethylamino)phenyl)phosphonio)palladium(II))dichloride; water; sodium carbonate / ethylene glycol dimethyl ether / 3 h / 85 °C / Inert atmosphere View Scheme
参考文献
Bethel, Paul A.; Campbell, Andrew D.; Goldberg, Frederick W.; Kemmitt, Paul D.; Lamont, Gillian M.; Suleman, Abid
Tetrahedron, 2012 , vol. 68, # 27-28 p. 5434 - 5444
反应条件
water; sodium hydrogencarbonate; potassium hexacyanoferrate(III)
参考文献
Bower; Ramage
Journal of the Chemical Society, 1957 , p. 4506,4509
反应条件
1: pyrazolo[1,5-a]-pyridine With n-butyllithium in tetrahydrofuran T=-78°C; 2: formic acid ethyl ester in tetrahydrofuran T=-78°C; 0.5 h;
参考文献
Loeber; Huebner; Utz; Gmeiner
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2691 - 2694
反应条件
n-butyllithium 1.) THF, hexane, -78 deg C, 30 min, 2a.) -78 deg C, 5 min, 2b.) -78 deg C to RT; Yield given. Multistep reaction;
参考文献
Finkelstein, Bruce L.
Journal of Organic Chemistry, 1992 , vol. 57, # 20 p. 5538 - 5540
参考文献
Tanji, Ken-ichi; Sasahara, Takehiko; Suzuki, Junko; Higashino, Takeo
Heterocycles, 1993 , vol. 35, # 2 p. 915 - 924
