1-甲基-1H-吡唑-5-甲醛合成路线 （共 6 条）
反应条件
1: 1-methyl-1H-pyrazole With n-butyllithium in tetrahydrofuran; hexane T=-20°C; 2.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-20°C; 1 h;
参考文献
LABORATORIOS DEL DR. ESTEVE, S.A.
Patent: EP1671968 A1, 2006 ;
Location in patent: Page/Page column 10 ;
反应条件
1: 1-methyl-1H-pyrazole With n-butyllithium in tetrahydrofuran; hexane T=-20°C; 2.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-20°C; 1 h;
参考文献
Jover, Antoni Torrens; Buschmann, Helmut H.; Dahmen, Stefan; Lormann, Matthias
Patent: US2006/135787 A1, 2006 ;
Location in patent: Page/Page column 3; 6-7 ;
反应条件
1: With sodium hydroxide in water T=0 - 20°C; 2: With hydrogenchloride in water 4 h; 3: With sodium hydroxide in water pH=9.4;
参考文献
BASF SE
Patent: US2010/174094 A1, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
n-butyllithium 1.) THF; Yield given. Multistep reaction;
参考文献
Azami, Hidenori; Barrett, David; Tanaka, Akira; Sasaki, Hiroshi; Matsuda, Keiji; Sakurai, Minora; Matsumoto, Yoshimi; Tawara, Shuichi; Chiba, Toshiyuki; Sakane, Kazuo
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 11 p. 1409 - 1414
反应条件
lithium aluminium tetrahydride in tetrahydrofuran cooling;
参考文献
Seto, Masaki; Miyamoto, Naoki; Aikawa, Katsuji; Aramaki, Yoshio; Kanzaki, Naoyuki; Iizawa, Yuji; Baba, Masanori; Shiraishi, Mitsuru
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 363 - 386
反应条件
sodium hydroxide in water T=70°C; Electrochemical reaction;
参考文献
Lyalin; Petrosyan
Russian Chemical Bulletin, 2012 , vol. 61, # 6 p. 1148 - 1153
Izv. Akad. Nauk, Ser. Khim., 2012 , vol. 61, # 6 p. 1139 - 1143,5
