反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 1 h / 25 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: trifluoroacetic acid; triethylsilane / 16 h / 20 - 55 °C 3.1: water; lithium hydroxide hydrate / tetrahydrofuran / 1 h / 20 °C 3.2: 0 °C / pH 5 View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; POPOVICI-MULLER, Janeta; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.; TRAVINS, Jeremey; YAN, Shunqi
Patent: WO2012/9678 A1, 2012 ;
WO 2012/009678 A1