2-氨基-3-硝基-6-氯吡啶合成路线 （共 36 条）
反应条件
ammonia in ethanol T=0°C; 3 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/27732 A1, 2009 ;
Location in patent: Page/Page column 69-70 ;
WO 2009/027732 A1
参考文献
UNIVERSITY OF SASKATCHEWAN
Patent: WO2007/45096 A1, 2007 ;
Location in patent: Page/Page column 39; 75 ;
反应条件
trichlorophosphate T=100°C;
参考文献
UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL
Patent: US2008/125358 A1, 2008 ;
Location in patent: Page/Page column 18 ;
反应条件
methoxylamine hydrochloride; potassium tert-butylate; zinc(II) chloride in various solvent(s) Ambient temperature;
参考文献
Seko, Shinzo; Miyake, Kunihito
Chemical Communications, 1998 , # 15 p. 1519 - 1520
反应条件
potassium permanganate; ammonia T=-33°C; 5 h;
参考文献
Wozniak, Marian; Baranski, Andrzej; Szpakiewicz, Barbara
Liebigs Annalen der Chemie, 1991 , # 9 p. 875 - 878
反应条件
potassium permanganate; ammonia; KNH2
参考文献
Bie, Dick A. de; Geursten, Bart; Plas, Henk C. van der
Journal of Organic Chemistry, 1985 , vol. 50, # 4 p. 484 - 487
反应条件
1: aq. NH3 / 72 h 2: HBr; AcOH / 60 °C 3: POCl3 / 100 °C View Scheme
参考文献
McClure, Kelly J.; Huang, Liming; Arienti, Kristen L.; Axe, Frank U.; Brunmark, Anders; Blevitt, Jon; Guy Breitenbucher
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1924 - 1928
反应条件
1: HBr; AcOH / 60 °C 2: POCl3 / 100 °C View Scheme
参考文献
McClure, Kelly J.; Huang, Liming; Arienti, Kristen L.; Axe, Frank U.; Brunmark, Anders; Blevitt, Jon; Guy Breitenbucher
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1924 - 1928
反应条件
1: sulfuric acid; nitric acid / -15 - 150 °C 2: ammonium hydroxide / 5 h / 50 °C View Scheme
参考文献
VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;
反应条件
1: With tin(ll) chloride in ethyl acetate; tert-butyl alcohol T=60°C; 1 h; 2: With sodium tetrahydroborate in ethyl acetate; tert-butyl alcohol T=60°C; 12 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/27732 A1, 2009 ;
Location in patent: Page/Page column 68 ;
WO 2009/027732 A1
