2-氯-5-硝基吡啶

2-氯-5-硝基吡啶

2-Chloro-5-nitropyridine

4548-45-2

C5H3ClN2O2

158.54300

58.71000

2.16640

157.98800

1.587

淡黄色至米色粉末

158°C

256.6ºC at 760 mmHg

106 °C

1.489 g/cm3

Stable at room temperature in closed containers under normal storage and handling conditions.

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

US7175000

3

S26-S36-S37/39

2933399090

Xi

R36/37/38

2933990090

2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

<p>由2-氨基吡啶经硝化、水解、氯化而得。<br>1.硝化将浓硫酸加入反应锅,维持50℃加入2-氨基吡啶,再在50℃滴加发烟硝酸。加毕,在45℃反应2h,在室温下搅拌4h。反应液倾入碎冰中,5℃以下加氨水调节至pH为6,析出结晶。过滤、干燥,用水重结晶,得2-氨基-5-硝基吡啶。<br>2.水解将2-氨基-5-硝基吡啶和10%氢氧化钠溶液混合,加热沸腾1h,热滤,滤液冷却,析出结晶。过滤,滤饼与水混合,加硫酸中和,过滤,干燥得2-羟基-5-硝基吡啶。<br>3.氯化将2-羟基-5-硝基吡啶、三氯氧磷和二甲基甲酰胺混合,回流2h。冷却,倒入碎冰中析出结晶。过滤、干燥,得成品。硝化、水解、氯化的总收率约为28%。</p>

<p>主要用于制药物及其他精细化学品。</p>