2-氨基-3-硝基-6-氯吡啶合成路线

16013-85-72,6-二氯-3-硝基吡啶→27048-04-02-氨基-3-硝基-6-氯吡啶

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/27732 A1, 2009 ;
Location in patent: Page/Page column 69-70 ;
WO 2009/027732 A1

16013-85-72,6-二氯-3-硝基吡啶→3346-63-22,6-二氨基-3-硝基吡啶+27048-04-02-氨基-3-硝基-6-氯吡啶

参考文献

UNIVERSITY OF SASKATCHEWAN
Patent: WO2007/45096 A1, 2007 ;
Location in patent: Page/Page column 39; 75 ;

211555-30-56-氨基-5-硝基-2(1H)-吡啶酮→27048-04-02-氨基-3-硝基-6-氯吡啶

参考文献

UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL
Patent: US2008/125358 A1, 2008 ;
Location in patent: Page/Page column 18 ;

4548-45-22-氯-5-硝基吡啶→2604-39-92-氯-4-氨基-5-硝基吡啶+27048-04-02-氨基-3-硝基-6-氯吡啶

参考文献

Seko, Shinzo; Miyake, Kunihito
Chemical Communications, 1998 , # 15 p. 1519 - 1520

4548-45-22-氯-5-硝基吡啶→52559-13-4+27048-04-02-氨基-3-硝基-6-氯吡啶

参考文献

Wozniak, Marian; Baranski, Andrzej; Szpakiewicz, Barbara
Liebigs Annalen der Chemie, 1991 , # 9 p. 875 - 878

4548-45-22-氯-5-硝基吡啶→4214-76-02-氨基-5-硝基吡啶+2604-39-92-氯-4-氨基-5-硝基吡啶

参考文献

Bie, Dick A. de; Geursten, Bart; Plas, Henk C. van der
Journal of Organic Chemistry, 1985 , vol. 50, # 4 p. 484 - 487

38533-61-82-氯-6-甲氧基-3-硝基吡啶→27048-04-02-氨基-3-硝基-6-氯吡啶

参考文献

McClure, Kelly J.; Huang, Liming; Arienti, Kristen L.; Axe, Frank U.; Brunmark, Anders; Blevitt, Jon; Guy Breitenbucher
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1924 - 1928

73896-36-32-氨基-6-甲氧基-3-硝酸吡啶→27048-04-02-氨基-3-硝基-6-氯吡啶

参考文献

McClure, Kelly J.; Huang, Liming; Arienti, Kristen L.; Axe, Frank U.; Brunmark, Anders; Blevitt, Jon; Guy Breitenbucher
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1924 - 1928

2402-78-02,6-二氯吡啶→27048-04-02-氨基-3-硝基-6-氯吡啶

参考文献

VITAS PHARMA RESEARCH PVT LTD; ALAPATI, Chandrasekhar; BANERJEE, Ankita; RANGARAJAN, Radha; KUMAR, Rajinder
Patent: WO2014/57415 A2, 2014 ;

27048-04-02-氨基-3-硝基-6-氯吡啶→40851-95-46-氯-2,3-二氨基吡啶

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/27732 A1, 2009 ;
Location in patent: Page/Page column 68 ;
WO 2009/027732 A1