3-甲基-1H-吲唑-5-甲腈合成路线 （共 3 条）
反应条件
acetic acid; sodium nitrite in water 16 h;
参考文献
D'Sidocky, Neil R.; Harris, Roy L.; Hegde, Sayee G.; Hilgraf, Robert; McCarrick, Margaret A.; McKie, Jeffrey A.; Mortensen, Deborah S.; Nadolny, Lisa; Perin-Ninkovic, Sophie M.; Sapienza, John J.; Wright, Jonathan L.
Patent: US2008/242694 A1, 2008 ;
Location in patent: Page/Page column 67-68 ;
US 20080242694 A1
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=95°C; 16 h;
参考文献
D'Sidocky, Neil R.; Harris, Roy L.; Hegde, Sayee G.; Hilgraf, Robert; McCarrick, Margaret A.; McKie, Jeffrey A.; Mortensen, Deborah S.; Nadolny, Lisa; Perin-Ninkovic, Sophie M.; Sapienza, John J.; Wright, Jonathan L.
Patent: US2008/242694 A1, 2008 ;
Location in patent: Page/Page column 41 ;
US 20080242694 A1
反应条件
1: 3-methyl-1H-indazole-5-carbonitrile; tert-butyl 5-cyano-3-methyl-1H-indazolecarboxylate; acetyl chloride in methanol T=60°C; 16 h; 2: With hydrogenchloride; water T=100°C; 3: ethanol; sulfuric acid T=85°C; 16 h;
参考文献
D'Sidocky, Neil R.; Harris, Roy L.; Hegde, Sayee G.; Hilgraf, Robert; McCarrick, Margaret A.; McKie, Jeffrey A.; Mortensen, Deborah S.; Nadolny, Lisa; Perin-Ninkovic, Sophie M.; Sapienza, John J.; Wright, Jonathan L.
Patent: US2008/242694 A1, 2008 ;
Location in patent: Page/Page column 40-41 ;
US 20080242694 A1
