1-(2-(4-硝基苯氧基)乙基)吡咯啉合成路线 （共 7 条）
反应条件
potassium carbonate in xylenes T=130°C;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2004/26823 A1, 2004 ;
Location in patent: Page 36 ;
WO 2004/026823 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 3 h;
参考文献
Pan, Xiaoyan; Dong, Jinyun; Gao, Hongping; Wang, Fang; Zhang, Yanmin; Wang, Sicen; Zhang, Jie
Chemical Biology and Drug Design, 2014 , vol. 83, # 5 p. 592 - 599
反应条件
sodium hydroxide; Nalco silica sol 1060 in tetrahydrofuran; methanol; chloroform; ethyl acetate
参考文献
ELI LILLY AND COMPANY
Patent: EP997460 A1, 2000 ;
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=0 - 20°C;
参考文献
Astex Therapeutics Ltd.
Patent: US2009/318441 A1, 2009 ;
Location in patent: Page/Page column 45-46 ;
参考文献
TARGEGEN, INC.
Patent: WO2007/53452 A1, 2007 ;
Location in patent: Page/Page column 65 ;
WO 2007/053452 A1
反应条件
potassium carbonate; xylene
参考文献
Kaye et al.
Journal of Organic Chemistry, 1951 , vol. 16, p. 1421,1424
反应条件
hydrogen; palladium 10 on activated carbon in methanol
参考文献
INCYTE CORPORATION
Patent: WO2009/64835 A1, 2009 ;
Location in patent: Page/Page column 168 ;
WO 2009/064835 A1
