2,5-二甲基噻吩-3-甲醛合成路线 （共 18 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate Cooling with ice; 2: 2,5-dimethyl-thiophene T=80°C; Cooling with ice; 3: With water; sodium acetate pH=5 - 6; Cooling;
参考文献
TRANSTECH PHARMA, INC.; MJALLI, Adnan, M., M.; GADDAM, Bapu; ANDREWS, Robert, C.; VICTORY, Samuel; GUPTA, Suparna
Patent: WO2010/25142 A1, 2010 ;
Location in patent: Page/Page column 43 ;
WO 2010/025142 A1
反应条件
aluminium trichloride in chlorobenzene T=3 - 20°C; Formylation; 1.5 h;
参考文献
Kantlehner, Willi; Vettel, Markus; Gissel, Alexander; Haug, Erwin; Ziegler, Georg; Ciesielski, Michael; Scherr, Oliver; Haas, Richard
Advanced Synthesis and Catalysis, 2000 , vol. 342, # 3 p. 297 - 310
反应条件
tin(IV) chloride in dichloromethane T=10°C;
参考文献
Glaze, Alan P.; Harris, Stuart A.; Heller, Harry G.; Johncock, William; Oliver, Stephen N.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 957 - 962
反应条件
titanium tetrachloride in dichloromethane T=5°C; 2 h;
参考文献
Belen'kii; Gromova; Kolotaev; Nabatov; Krayushkin
Russian Chemical Bulletin, 2005 , vol. 54, # 5 p. 1208 - 1213
反应条件
palladium on activated charcoal; xylene Hydrogenation;
参考文献
Brown; Blanchette
Journal of the American Chemical Society, 1950 , vol. 72, p. 3414
反应条件
1: POCl3 / 3.5 h / 20 - 80 °C 2: aq. NaOH / dimethylformamide / 10 °C / pH 10 View Scheme
参考文献
Dallemagne, Patrick; Khanh, Lan Pham; Alsadi, Abdellah; Renault, Olivier; Varlet, Isabelle; Collot, Valerie; Bureau, Ronan; Rault, Sylvain
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 7 p. 2185 - 2191
反应条件
1: hydrazine hydrate; potassium hydroxide; ethylene glycol 2: phosphoryl chloride / anschliessendes Behandeln mit wss. Natriumacetat View Scheme
参考文献
King; Nord
Journal of Organic Chemistry, 1949 , vol. 14, p. 638,639
反应条件
trichlorophosphate anschliessendes Behandeln mit wss. Natriumacetat;
参考文献
King; Nord
Journal of Organic Chemistry, 1949 , vol. 14, p. 638,639
参考文献
Comins, Daniel L.; Killpack, Michael O.
Journal of Organic Chemistry, 1987 , vol. 52, # 1 p. 104 - 109
反应条件
Yield given. Multistep reaction;
参考文献
Comins, Daniel L.; Killpack, Michael O.
Journal of Organic Chemistry, 1987 , vol. 52, # 1 p. 104 - 109
