alpha-溴-4-甲氧基苯乙酮合成路线 （共 261 条）
反应条件
1: 50percent NaH / tetrahydrofuran / 0.5 h / Ambient temperature 2: acetic anhydride / 0.25 h / 40 °C View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
参考文献
Kamila, Sukanta; Zhu, Dunming; Biehl, Edward R.; Hua, Ling
Organic Letters, 2006 , vol. 8, # 20 p. 4429 - 4431
参考文献
American Cyanamid Company
Patent: US4173650 A1, 1979 ;
反应条件
tetrabutylammomium bromide in water T=20°C; 1.5 h;
参考文献
Sayyahi, Soheil; Saghanezhad, Jafar
Chinese Chemical Letters, 2011 , vol. 22, # 3 p. 300 - 302
反应条件
in ethanol; water T=20°C; Substitution; 2 h;
参考文献
Baraldi, Pier Giovanni; Zaid, Abdel Naser; Lampronti, Ilaria; Fruttarolo, Francesca; Pavani, Maria Giovanna; Tabrizi, Mojgan Aghazadhe; Shryock, John C.; Leung, Edward; Romagnoli, Romeo
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 1953 - 1957
反应条件
1: With diformylimide sodium salt in acetonitrile T=20 - 70°C; 4 h; 2: With hydrogenchloride in ethanol 1 h; Heating / reflux;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/18428 A1, 2004 ;
Location in patent: Page 356 ;
反应条件
hydrogenchloride; sodium iodide in ethanol
参考文献
Canon Kabushiki Kaisha
Patent: US5217645 A1, 1993 ;
反应条件
hydrogenchloride 1a) EtOH, RT, 2h, 1b) 50 deg C, 30 min, 2) 30 min, reflux; Yield given. Multistep reaction;
参考文献
Yinglin, Han; Hongwen, Hu
Synthesis, 1990 , # 7 p. 615 - 618
反应条件
1: sodium azide / ethanol / 24 h / 20 °C 2: triphenylphosphine / tetrahydrofuran View Scheme
参考文献
Widler, Leo; Green, Jonathan; Missbach, Martin; Susa, Mira; Altmann, Eva
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 849 - 852
反应条件
1: 79 percent / K2CO3 / dimethylformamide / 2 h / 100 - 120 °C 2: 70 percent / BBr3 / CH2Cl2 / 72 h / 20 °C View Scheme
参考文献
Sadek, Bassem; Fahelelbom, Khairi Mustafa Salem
Molecules, 2011 , vol. 16, # 6 p. 4339 - 4347
