4-氯-7-羟基-6-甲氧基喹啉-3-甲腈合成路线 （共 13 条）
反应条件
methyl-phenyl-thioether; trifluoroacetic acid 3 h; Heating / reflux;
参考文献
AstraZeneca AB
Patent: EP1584619 A1, 2005 ;
Location in patent: Page/Page column 41-42 ;
EP 1584619 A1
反应条件
aluminium trichloride dealkylation;
参考文献
Cao, Xin; You, Qi-Dong; Li, Zhi-Yu; Liu, Xiao-Rong; Xu, Dan; Guo, Qing-Long; Shang, Jing; Chern, Ji-Wang; Chen, Meng-Ling
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6206 - 6209
反应条件
1.1: HNO3 2.1: Fe; NH4Cl 3.2: n-BuLi 4.1: POCl3 5.1: AlCl3 View Scheme
参考文献
Wang, Yanong D.; Miller, Karen; Boschelli, Diane H.; Ye, Fei; Wu, Biqi; Floyd; Powell, Dennis W.; Wissner, Allan; Weber, Jennifer M.; Boschelli, Frank
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 21 p. 2477 - 2480
反应条件
1.1: HNO3 2.1: Fe; NH4Cl 3.2: n-BuLi 4.1: POCl3 5.1: AlCl3 View Scheme
参考文献
Wang, Yanong D.; Miller, Karen; Boschelli, Diane H.; Ye, Fei; Wu, Biqi; Floyd; Powell, Dennis W.; Wissner, Allan; Weber, Jennifer M.; Boschelli, Frank
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 21 p. 2477 - 2480
反应条件
1.2: n-BuLi 2.1: POCl3 3.1: AlCl3 View Scheme
参考文献
Wang, Yanong D.; Miller, Karen; Boschelli, Diane H.; Ye, Fei; Wu, Biqi; Floyd; Powell, Dennis W.; Wissner, Allan; Weber, Jennifer M.; Boschelli, Frank
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 21 p. 2477 - 2480
反应条件
1.1: Fe; NH4Cl 2.2: n-BuLi 3.1: POCl3 4.1: AlCl3 View Scheme
参考文献
Wang, Yanong D.; Miller, Karen; Boschelli, Diane H.; Ye, Fei; Wu, Biqi; Floyd; Powell, Dennis W.; Wissner, Allan; Weber, Jennifer M.; Boschelli, Frank
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 21 p. 2477 - 2480
反应条件
1: POCl3 2: AlCl3 View Scheme
参考文献
Wang, Yanong D.; Miller, Karen; Boschelli, Diane H.; Ye, Fei; Wu, Biqi; Floyd; Powell, Dennis W.; Wissner, Allan; Weber, Jennifer M.; Boschelli, Frank
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 21 p. 2477 - 2480
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=0°C; Mitsunobu conditions; 0.25 h;
参考文献
Boschelli; Ye; Wang; Dutia; Johnson; Wu; Miller; Powell; Yaczko; Young; Tischler; Arndt; Discafani; Etienne; Gibbons; Grod; Lucas; Weber
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3965 - 3977
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in dichloromethane T=0 - 20°C; Mitsunobu reaction;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 21 p. 5978 - 5982
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/5284 A1, 2004 ;
Location in patent: Page 80 ;
WO 2004/005284 A1
