2-溴-2',4'-二氯苯乙酮合成路线 （共 26 条）
反应条件
trimethylsilyl bromide; potassium nitrate in dichloromethane T=20°C; 48 h;
参考文献
Prakash, G.K. Sxurya; Ismail, Rehana; Garcia, Jessica; Panja, Chiradeep; Rasul, Golam; Mathew, Thomas; Olah, George A.
Tetrahedron Letters, 2011 , vol. 52, # 11 p. 1217 - 1221
反应条件
bromine in 1,4-dioxane; diethyl ether 0.5 h; Ambient temperature;
参考文献
Rival; Taudou; Ecalle
Farmaco, 1993 , vol. 48, # 6 p. 857 - 869
反应条件
bromine in acetic acid T=35 - 40°C; 2 h;
参考文献
Kopka, Ihor E.; Li, Bing; Hagmann, William K.
Patent: US2005/245554 A1, 2005 ;
Location in patent: Page/Page column 33 ;
US 20050245554 A1
参考文献
Schering A.G.
Patent: US4920116 A1, 1990 ;
反应条件
in methanol 0.25 h; Heating; Title compound not separated from byproducts;
参考文献
Mlotkowska, Barbara; Majewski, Piotr; Koziara, Anna; Zwierzak, Andrzej; Sledzinski, Bohdan
Polish Journal of Chemistry, 1981 , vol. 55, # 3 p. 631 - 642
反应条件
1: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 2: acetic anhydride / 0.25 h / 40 °C View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
反应条件
1: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 2: acetic anhdride / 0.25 h / 40 °C View Scheme
参考文献
Ogata, Masaru; Matsumoto, Hiroshi; Kida, Shiro; Shimizu, Sumio; Tawara, Katsuya; Kawamura, Yoshimi
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1497 - 1502
参考文献
Kamila, Sukanta; Zhu, Dunming; Biehl, Edward R.; Hua, Ling
Organic Letters, 2006 , vol. 8, # 20 p. 4429 - 4431
反应条件
potassium tert-butylate in tetrahydrofuran
参考文献
American Cyanamid Company
Patent: US5101042 A1, 1992 ;
反应条件
in tetrahydrofuran T=20°C; 1.5 h; Inert atmosphere;
参考文献
Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Malpartida, Francisco; Gotor, Vicente
Journal of Organic Chemistry, 2011 , vol. 76, # 7 p. 2115 - 2122
