(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
NH4Br; ethylenediamine T=80°C; 10 h; Microwave irradiationInert atmosphereneat (no solvent);
参考文献
Shimizu, Yuhei; Morimoto, Hiroyuki; Zhang, Ming; Ohshima, Takashi
Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8564 - 8567
反应条件
trifluoroacetic acid in methanol T=25°C; 3 h;
参考文献
Hua, Duy H.; Miao, Shou Wu; Chen, Jin Shan; Iguchi, Sadahiko
Journal of Organic Chemistry, 1991 , vol. 56, # 1 p. 4 - 6
反应条件
1: With borane-THF; (S)-proline (R)-1,1'-bi(2-naphthyl)dioxyboryl ester in tetrahydrofuran T=0 - 5°C; 48 h; 2: With hydrogenchloride in tetrahydrofuran
参考文献
Chu, Yunbo; Shan, Zixing; Liu, Dejun; Sun, Nannan
Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 3998 - 4001
反应条件
pyridoxal 5'-phosphate in aq. phosphate buffer; dimethyl sulfoxide T=30°C; pH=7.5; 24 h; Resolution of racemateEnzymatic reaction; Reagent/catalyst; enantioselective reaction;
参考文献
Paeivioe, Mari; Kanerva, Liisa T.
Process Biochemistry, 2013 , vol. 48, # 10 p. 1488 - 1494
反应条件
sodium hydroxide in water; ethylene glycol T=110°C; 13 h;
参考文献
Tsunoda, Tetsuto; Sasaki, Osamu; Takeuchi, Osamu; Ito, Sho
Tetrahedron, 1991 , vol. 47, # 24 p. 3925 - 3934
反应条件
pyridoxal 5'-phosphate in aq. phosphate buffer T=30°C; pH=7.5; 24 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Paeivioe, Mari; Kanerva, Liisa T.
Process Biochemistry, 2013 , vol. 48, # 10 p. 1488 - 1494
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. phosphate buffer T=37°C; pH=7.4; 12 h; Enzymatic reaction; enantioselective reaction;
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
反应条件
hydrogenchloride; (+)-ketopinic acid; water; lithium diisopropyl amide Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Shin, Jong-Shik; Kim, Byung-Gee
Bioscience, Biotechnology and Biochemistry, 2001 , vol. 65, # 8 p. 1782 - 1788
反应条件
2-mercapto benzoic acid; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran T=60°C; 0.25 h;
参考文献
Lemaire-Audoire; Lemaire-Audoire, Sandrine; Savignac; Savignac, Monique; Genet; Genet, Jean Pierre; Bernard; Bernard, Jean-Marie
Tetrahedron Letters, 1995 , vol. 36, # 8 p. 1267 - 1270
反应条件
1: With titanium(IV) isopropylate; hydrogen; iodine; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (S,S)-f-binaphane in dichloromethane T=20°C; P=51714.8 Torr; 10 h; 2: With ammonium cerium(IV) nitrate in methanol; water T=0°C; 6 h; Title compound not separated from byproducts;
参考文献
Chi, Yongxiang; Zhou, Yong-Gui; Zhang, Xumu
Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 4120 - 4122
