6-溴-2-吡啶甲酸甲酯合成路线 （共 18 条）
反应条件
1: With sulfuric acid 4 h; Heating / reflux; 2: With ammonia in water T=0°C;
参考文献
WO2003/84917 A1, ;
Page/Page column 26 ;
反应条件
methanol; sulfuric acid Heating / reflux;
参考文献
US2006/235028 A1, ;
Page/Page column 32 ;
US 20060235028 A1
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) 18 h; Product distribution / selectivity;
参考文献
WO2005/97768 A2, ;
Page/Page column 79-80 ;
WO 2005/097768 A2
反应条件
water; iodine; sodium nitrite T=20 - 70°C; chemoselective reaction;
参考文献
Synthesis, , # 2 art. no. F16609SS, p. 276 - 282
反应条件
1: 1.) n-BuLi, 2.) HCl / 1.) THF, -78 deg C, 15 min 2: Cs2CO3 / dimethylformamide / 55 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 16 p. 2117 - 2122
参考文献
Journal of Organic Chemistry, , vol. 16, p. 1485,1491
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride in 1,4-dioxane 48 h; Heating / reflux; 2: With potassium fluoride in water; ethyl acetate 0.5 h;
参考文献
SCHERING CORPORATION
Patent: WO2005/97768 A2, 2005 ;
Location in patent: Page/Page column 80 ;
WO 2005/097768 A2
反应条件
sodium tetrahydroborate in ethanol 2 h; Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 30, # 2 p. 563 - 565
反应条件
in N,N-dimethyl-formamide T=150°C; Rosenmund von Braun synthesis; 0.0833333 h; Microwave irradiation;
参考文献
Andreiadis, Eugen S.; Imbert, Daniel; Pecaut, Jacques; Demadrille, Renaud; Mazzanti, Marinella
Dalton Transactions, 2012 , vol. 41, # 4 p. 1268 - 1277
反应条件
1: 70 percent / NaBH4 / ethanol / 2 h / Heating 2: 89 percent / NaH / tetrahydrofuran / 2.5 h / 5 - 20 °C 3: 71 percent / aq. NH3 / 10 h / 200 °C View Scheme
参考文献
Shawcross, Andrew P.; Stanforth, Stephen P.
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 2 p. 563 - 565
