6-[[[5-(2,4-二氧代嘧啶-1-基)-3,4-二羟基四氢呋喃-2-基]甲氧基-羟基磷酰]氧基-羟基磷酰]氧基-3,4,5-三羟基四氢吡喃-2-羧酸合成路线 (共 17 条)
反应条件
immobilized male Beagle dog liver microsomes in water-d2 T=25°C; phosphate bufferEnzymatic reaction;
参考文献
Kashima, Yousuke; Okabayashi, Yoshito
Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 3 p. 423 - 425
反应条件
Tris-HCl buffer; human liver microsomes; magnesium chloride T=37°C; pH=7.4; 0.666667 h; Enzyme kinetics; Further Variations:Reagents;
参考文献
Xenobiotica, , vol. 31, # 10 p. 687 - 699
反应条件
Brij 58; pooled human liver microsomes; magnesium chloride in phosphate buffer T=37.5°C; pH=5.5; 4 h; Enzyme kinetics; Further Variations:pH-valuesTemperaturesSolventsincubation time; molar ratios;
参考文献
Boldt, Petra; Rothschild, Markus A.; Kaeferstein, Herbert
Arzneimittel-Forschung/Drug Research, 2007 , vol. 57, # 12 p. 787 - 794
反应条件
Tris-HCl buffer; UDP-glucuronate: baicalein 7-O-glucuronosyltransferase in water T=37°C; Esterification; pH=7.5; Enzymatic reaction; Enzyme kinetics;
参考文献
Nagashima, Shigeyuki; Hirotani, Masao; Yoshikawa, Takafumi
Phytochemistry, 2000 , vol. 53, # 5 p. 533 - 538
反应条件
recombinant human UDP-glucuronosyltransferase 1A8 1 h; Enzymatic reaction; Kinetics; ConcentrationReagent/catalystTime; regioselective reaction;
参考文献
Wu, Baojian; Xu, Beibei; Hu, Ming
Pharmaceutical Research, 2011 , vol. 28, # 8 p. 1905 - 1918
反应条件
Veronica persica UDP-dependent glycosyl transferase 88D8 in potassium phosphate buffer T=30°C; pH=7.5; Kinetics;
参考文献
Ono, Eiichiro; Ruike, Miho; Iwashita, Takashi; Nomoto, Kyosuke; Fukui, Yuko
Phytochemistry, 2010 , vol. 71, # 7 p. 726 - 735
反应条件
human liver microsomes
T=37°C; pH=7.5; 1 h; aq. buffer; Kinetics; Reagent/catalyst;
参考文献
Seo, Kyung-Ah; Bae, Soo Kyung; Choi, Young-Kil; Choi, Chang Soo; Liu, Kwang-Hyeon; Shin, Jae-Gook
Drug Metabolism and Disposition, 2010 , vol. 38, # 11 p. 2007 - 2013