2-氯-4-氨基-5-硝基吡啶合成路线 （共 16 条）
反应条件
1: With sulfuric acid T=20 - 100°C; 1 h; 2: With ammonia in water T=20°C; pH=3;
参考文献
Yin, Xueqiang; Schneller, Stewart W
Nucleosides, nucleotides and nucleic acids, 2004 , vol. 23, # 1-2 p. 67 - 76
反应条件
1: With sulfuric acid T=85 - 110°C; 3 h; 2: With ammonia in water pH=9;
参考文献
4SC AG
Patent: EP2017277 A1, 2009 ;
Location in patent: Page/Page column 31 ;
EP 2017277 A1
反应条件
1: With sulfuric acid; nitric acid in water T=0 - 5°C; 0.5 h; 2: With ammonia; water pH=~ 3; 3: With sulfuric acid; ammonia; water more than 3 stages;
参考文献
Yoo, Euna; Crall, Breanna M.; Balakrishna, Rajalakshmi; Malladi, Subbalakshmi S.; Fox, Lauren M.; Hermanson, Alec R.; David, Sunil A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 38 p. 6526 - 6545
反应条件
1: nitric acid; sulfuric acid / 0.5 h / 0 °C 2: sulfuric acid / 1.5 h / 75 °C View Scheme
参考文献
Sun, Li-Qiang; Zhao, Qian; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshim, Pulicharla; Gillis, Eric P.; Scola, Paul Michael
Patent: US2014/127156 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
methoxylamine hydrochloride; potassium tert-butylate; zinc(II) chloride in various solvent(s) Ambient temperature;
参考文献
Seko, Shinzo; Miyake, Kunihito
Chemical Communications, 1998 , # 15 p. 1519 - 1520
反应条件
potassium permanganate; ammonia; KNH2
参考文献
Bie, Dick A. de; Geursten, Bart; Plas, Henk C. van der
Journal of Organic Chemistry, 1985 , vol. 50, # 4 p. 484 - 487
参考文献
Talik; Plazek
Roczniki Chemii, 1956 , vol. 30, p. 1139,1144
Chem.Abstr., 1957 , p. 12089
反应条件
in ammonium hydroxide
参考文献
Sircar, Jagadish C.; Thomas, Richard J.; Richards, Mark L.; Sinha, Anjana
Patent: US2004/116466 A1, 2004 ;
反应条件
iron; ytterbium(III) triflate T=75°C; 3 h;
参考文献
Wang, Fen; Tran-Dube, Michelle; Scales, Stephanie; Johnson, Sarah; McAlpine, Indrawan; Ninkovic, Sacha
Tetrahedron Letters, 2013 , vol. 54, # 31 p. 4054 - 4057
反应条件
iron; ammonium chloride in isopropyl alcohol T=120°C; 24 h;
参考文献
Hanan, Emily J.; Chan, Bryan K.; Estrada, Anthony A.; Shore, Daniel G.; Lyssikatos, Joseph P.
Synlett, 2010 , # 18 p. 2759 - 2764
