1,3,3-三甲基-2-[(1E,3E)-3-甲基-1,3-己二烯-5-炔基]-环己烷合成路线 （共 5 条）
反应条件
1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); isopropylamine / 3.5 h 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C 3: zinc / water; isopropyl alcohol / 26 h / 40 °C View Scheme
参考文献
McLean, Neville J.; Gansmuller, Axel; Concistre, Maria; Brown, Lynda J.; Levitt, Malcom H.; Brown, Richard C.D.
Tetrahedron, 2011 , vol. 67, # 43 p. 8404 - 8410
反应条件
1: 79 percent / Pd(PPH3)4; CuI; i-PrNH2 / 20 °C 2: 89 percent / TBAF / tetrahydrofuran / 20 °C View Scheme
参考文献
McLean, Neville J.; Gansmuller, Axel; Concistre, Maria; Brown, Lynda J.; Levitt, Malcom H.; Brown, Richard C.D.
Tetrahedron, 2011 , vol. 67, # 43 p. 8404 - 8410
反应条件
1.1: Bu3SnCu(Bu)CNLi2 / tetrahydrofuran / -78 °C 1.2: 60 percent / Ph3As / Pd2(dba)3 / tetrahydrofuran; dimethylformamide / 20 °C 2.1: 83 percent / KOH / ethanol View Scheme
参考文献
Wada; Fukunaga; Ito
Synlett, 2001 , # 6 p. 800 - 802
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); isopropylamine
T=20°C;
参考文献
Lai, Wai Cheu; McLean, Neville; Gansmueller, Axel; Verhoeven, Michiel A.; Antonioli, Gian Carlo; Carravetta, Marina; Duma, Luminita; Bovee-Geurts, Petra H. M.; Johannessen, Ole G.; De Groot, Huub J. M.; Lugtenburg, Johan; Emsley, Lyndon; Brown, Steven P.; Brown, Richard C. D.; DeGrip, Willem J.; Levitt, Malcolm H.
Journal of the American Chemical Society, 2006 , vol. 128, # 12 p. 3878 - 3879
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); isopropylamine
Sonogashira reaction; 3.5 h;
参考文献
McLean, Neville J.; Gansmuller, Axel; Concistre, Maria; Brown, Lynda J.; Levitt, Malcom H.; Brown, Richard C.D.
Tetrahedron, 2011 , vol. 67, # 43 p. 8404 - 8410
