4-乙氧基-3-羟基苯甲醛合成路线 （共 18 条）
反应条件
1: With ethylene glycol; orthoformic acid triethyl ester; boron trifluoride diethyl etherate T=100°C; 24 h; Heating / reflux; 2: With lithium diphenylphosphinide in tetrahydrofuran T=20°C; 3 - 4 h; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;
参考文献
Zhejiang Dade Pharmaceutical Group Co. Ltd
Patent: US2009/170956 A1, 2009 ;
Location in patent: Page/Page column 7-8; fig.1 ;
反应条件
1: With lithium diphenylphosphinide in tetrahydrofuran T=20°C; 3 - 4 h; 2: With sodium hydroxide; water in tetrahydrofuran 3: With hydrogenchloride; water pH=3 - 4;
参考文献
Zhejiang Dade Pharmaceutical Group Co., Ltd.
Patent: EP2065358 A1, 2009 ;
Location in patent: Page/Page column 11; 19 ;
反应条件
in water; ethyl acetate; N,N-dimethyl-formamide; mineral oil
参考文献
Peng, Ge; Gallop, Mark A.; Chernov-Rogan, Tania; Yanofsky, Stephen D.; Pelletier, Jeffrey Claude; Green, Daniel Michael
Patent: US2002/65309 A1, 2002 ;
US 20020065309 A1
反应条件
sodium iodide in N,N-dimethyl-formamide
参考文献
Dynapol Corporation
Patent: US4025535 A1, 1977 ;
参考文献
Gurudutt,K.N.; Seshadri,T.R.
Phytochemistry (Elsevier), 1974 , vol. 13, p. 2845 - 2847
反应条件
1.1: sodium hydroxide / 18-crown-6 ether / isopropyl alcohol; water / 0.5 h 1.2: 60 °C 2.1: orthoformic acid triethyl ester / boron trifluoride diethyl etherate / 24 h / 100 °C / Inert atmosphere 3.1: lithium diphenylphosphinide / tetrahydrofuran / 20 °C 3.3: pH 3 - 4 View Scheme
参考文献
Shanghai Ecust Biomedicine Co., Ltd; Zhejiang Wild Wind Pharmaceutical Co., Ltd
Patent: EP2351730 A1, 2011 ;
参考文献
Hirao
Nippon Kagaku Kaishi, 1931 , vol. 52, p. 26,29
Chem.Abstr., 1931 , p. 5156
反应条件
chloroform; ozone und Zersetzen des entstandenen Ozonids mit Kaliumferrocyanid;
参考文献
Kafuku; Itikawa
Yakugaku Zasshi, 1926 , # 531 p. 35
Chem. Zentralbl., 1926 , vol. 97, # II p. 1138
反应条件
hydrogen bromide Reaktion ueber mehrere Stufen;
参考文献
King
Journal of the Chemical Society, 1939 , p. 1159
Journal of the Chemical Society, 1948 , p. 265
反应条件
1: aq.-ethanolic NaOH / 140 °C 2: aqueous methanol; palladium / Hydrogenation View Scheme
参考文献
Kindler; Gehlhaar
Archiv der Pharmazie (Weinheim, Germany), 1936 , vol. 274, p. 377,385
