N-(6-溴吡啶-2-基)乙酰胺合成路线 （共 7 条）
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
GLAXOSMITHKLINE LLC; BOUILLOT, Anne Marie Jeanne; DAUGAN, Alain Claude-Marie; LAMOTTE, Yann; MIRGUET, Olivier
Patent: WO2012/119979 A1, 2012 ;
Location in patent: Page/Page column 34-35 ;
WO 2012/119979 A1
参考文献
Colgate-Palmolive Company
Patent: US4048181 A1, 1977 ;
参考文献
WO2009/145360 A1, ;
Page/Page column 66-67 ;
WO 2009/145360 A1
反应条件
hydrogen bromide; sodium nitrite in water 1 h;
参考文献
Ferrarini; Biagi; Livi; et al.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 5 p. 1007 - 1010
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate / toluene / 70 °C / |Inert atmosphere 2: sodium hydroxide / water; ethanol / |Reflux View Scheme
参考文献
Yi, Bitna; Long, Sihui; Gonzalez-Cestari, Tatiana F.; Henderson, Brandon J.; Pavlovicz, Ryan E.; Werbovetz, Karl; Li, Chenglong; McKay, Dennis B.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4730 - 4743
反应条件
sulfuric acid; nitric acid in water T=0°C; 4 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/141119 A2, 2008 ;
Location in patent: Page/Page column 84 ;
WO 2008/141119 A2
反应条件
sulfuric acid in water
参考文献
Ferrarini; Biagi; Livi; et al.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 5 p. 1007 - 1010
