2-氯-5-硝基苯甲酸合成路线 （共 155 条）
反应条件
in water
T=20 - 65°C; 3 h; Product distribution / selectivity;
参考文献
F2G LTD
Patent: WO2006/123145 A1, 2006 ;
Location in patent: Page/Page column 67 ;
反应条件
T=120°C; 0.25 h; microwave irradiation;
参考文献
Baqi, Younis; Mueller, Christa E.
Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5908 - 5911
参考文献
Nagarajan,K. et al.
Indian Journal of Chemistry, 1974 , vol. 12, p. 236 - 246
反应条件
1: 2-carboxy-4-nitro-chlorobenzene With thionyl chloride; N,N-dimethyl-formamide in toluene
1.5 h; Heating / reflux;
2: potassium tert-butylate in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2008/152014 A2, 2008 ;
Location in patent: Page/Page column 15 ;
WO 2008/152014 A2
反应条件
thionyl chloride in tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide
参考文献
Cancer Research Campaign Technology Limited
Patent: US5985909 A1, 1999 ;
反应条件
sulfuric acid in dichloromethane
T=20°C; Esterification; 48 h;
参考文献
Van Der Aar; Buikema; Commandeur; Te Koppele; Van Ommen; Van Bladeren; Vermeulen
Xenobiotica, 1996 , vol. 26, # 2 p. 143 - 155
反应条件
1.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / |Reflux
1.2: |Cooling with ice
2.1: sodium / 2 h / |Reflux
View Scheme
参考文献
Lori, Franco; Chafouleas, James; De Forni, Davide; Solinas, Antonio; Varga, Zoltán; Greff, Zoltán; Örfi, László; Kéri, György
Patent: US2014/57911 A1, 2014 ;
反应条件
potassium carbonate in water
T=150°C; 2 h;
参考文献
Lan, Cong; Xia, Zhi-Ning; Li, Zheng-Hua; Liang, Rong-Hui
Journal of Chemical Research, 2012 , vol. 36, # 12 p. 726 - 728
反应条件
sodium hydroxide in pentan-1-ol
参考文献
Schering Corporation
Patent: US4029815 A1, 1977 ;
反应条件
potassium carbonate in water
T=150°C; 2 h;
参考文献
Lan, Cong; Xia, Zhi-Ning; Li, Zheng-Hua; Liang, Rong-Hui
Journal of Chemical Research, 2012 , vol. 36, # 12 p. 726 - 728
