1: 2-bromo-2'-methylbiphenyl With n-butyllithium in tetrahydrofuran T=-78°C; Metallation; 1.16667 h; 2: chloro-dicyclohexylphosphine in tetrahydrofuran Condensation; a) -78 deg C, 20 min, b) 0 deg C, 20 min, c) RT, 18 h;

1: 2-methylphenylmagnesium chloride With magnesium in tetrahydrofuran 0.25 h; Heating; 2: 1-bromo-2-chloro-benzene in tetrahydrofuran 2 h; Heating; 3: chloro-dicyclohexylphosphine in tetrahydrofuran T=20°C; 14 h; Further stages.;

1: 2-chloro-2'-methylbiphenyl With sec.-butyllithium in diethyl ether; cyclohexane T=-78 - -45°C; Inert atmosphere; 2: chloro-dicyclohexylphosphine in diethyl ether; cyclohexane T=-78°C; Inert atmosphere;

1.1: 1.57 g / tetrakis(triphenylphosphine)palladium; Na2CO3 / 1,2-dimethoxy-ethane; H2O; ethanol / 42 h / 90 °C 2.1: n-BuLi / tetrahydrofuran / 1.17 h / -78 °C 2.2: 65 percent / tetrahydrofuran / a) -78 deg C, 20 min, b) 0 deg C, 20 min, c) RT, 18 h View Scheme

1.1: 1.57 g / tetrakis(triphenylphosphine)palladium; Na2CO3 / 1,2-dimethoxy-ethane; H2O; ethanol / 42 h / 90 °C 2.1: n-BuLi / tetrahydrofuran / 1.17 h / -78 °C 2.2: 65 percent / tetrahydrofuran / a) -78 deg C, 20 min, b) 0 deg C, 20 min, c) RT, 18 h View Scheme

1.1: PCl3 / diethyl ether / -40 - 20 °C 2.1: Mg / tetrahydrofuran / 0.25 h / Heating 2.2: tetrahydrofuran / 2 h / Heating 2.3: 51 percent / tetrahydrofuran / 14 h / 20 °C View Scheme

1.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; (Me)CgPPh / toluene / 70 °C / Inert atmosphere 2.1: sec.-butyllithium / diethyl ether; cyclohexane / -78 - -45 °C / Inert atmosphere 2.2: -78 °C / Inert atmosphere View Scheme

1: 1-bromo-2-methyl benzene With magnesium; ethylene dibromide in tetrahydrofuran 2 h; Inert atmosphereRefluxIndustrial scale; 2: 1-bromo-2-chloro-benzene With magnesium in tetrahydrofuran 2 h; Inert atmosphereRefluxIndustrial scale; 3: chloro-dicyclohexylphosphine With copper(l) chloride in tetrahydrofuran T=20°C; Inert atmosphereIndustrial scale; Thermodynamic data;

Multistep reaction.;