2-(2,3-二氢噻吩并[3,4-b][1,4]二噁英-5-基)-4,4,5,5-四甲基-1,3,2-二噁硼烷合成路线 （共 7 条）
反应条件
1: 2,3-dihydro-thieno[3,4-b][1,4]dioxine With n-butyllithium in tetrahydrofuran T=-78°C; 1 h; Inert atmosphere; 2: tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; 2.5 h; Inert atmosphere; 3: 2,3-dimethylbutane-2,3-diol in tetrahydrofuran 0.5 h; Inert atmosphere;
参考文献
Tetrahedron, , vol. 69, # 2 p. 861 - 866
反应条件
1: 3,4-ethylenedioxythiophene With n-butyllithium in tetrahydrofuran T=-78 - 0°C; Inert atmosphere; 2: 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane in tetrahydrofuran T=20°C; 17 h; Inert atmosphere;
参考文献
European Journal of Organic Chemistry, , # 12 p. 2118 - 2129
反应条件
n-butyllithium in tetrahydrofuran T=-78 - 20°C; Substitution; 6 h;
参考文献
Tetrahedron, , vol. 55, # 40 p. 11745 - 11754
反应条件
1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - 0 °C / |Inert atmosphere; |Schlenk technique 2: tetrahydrofuran / -78 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 20 p. 8851 - 8863
反应条件
in tetrahydrofuran T=-78°C; Inert atmosphereSchlenk technique;
参考文献
Journal of Organic Chemistry, , vol. 77, # 20 p. 8851 - 8863
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in water; N,N-dimethyl-formamide T=170°C; 0.333333 h; Microwave irradiation;
参考文献
TARGEGEN INC.
Patent: WO2009/26345 A1, 2009 ;
Location in patent: Page/Page column 34-35 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in N,N-dimethyl-formamide
T=80°C; Suzuki cross-coupling;
参考文献
Mohanakrishnan, Arasambattu K.; Amaladass; Arul Clement
Tetrahedron Letters, 2007 , vol. 48, # 4 p. 539 - 544
