3-环戊基-3-氧代丙酸乙酯合成路线 （共 11 条）
反应条件
1: propanedioic acid monoethyl ester With [2,2']bipyridinyl; n-butyllithium in hexanes T=-65 - -55°C; 2: cyclopentane carboxylic acid chloride in hexanes T=20°C;
参考文献
SmithKline Beecham Corporation
Patent: US2008/96921 A1, 2008 ;
Location in patent: Page/Page column 42 ;
反应条件
triethylamine; magnesium chloride in acetonitrile T=0°C; 4 h;
参考文献
MERZ PHARMA GMBH and; CO. KGAA; HENRICH, Markus; BAUER, Angela; KRUeGER, Bjoern; KAUSS, Valerjans; MUeLLER, Sibylle; KUBAS, Holger; ROZHKOVS, Jevgenijs; PISKUNOVA, Irene
Patent: WO2010/139483 A1, 2010 ;
Location in patent: Page/Page column 67-68 ;
反应条件
in neat (no solvent) T=110°C;
参考文献
Sakai, Takashi; Amano, Eiichiro; Kawabata, Akifumi; Takeda, Akira
Journal of Organic Chemistry, 1980 , vol. 45, # 1 p. 43 - 47
反应条件
copper(II) sulfate T=20°C; 3 h;
参考文献
Liao, Mingyi; Wang, Jianbo
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8859 - 8861
反应条件
diethyl ether; ammonia
参考文献
Journal of the American Chemical Society, , vol. 70, p. 497,499
参考文献
Sakai, Takashi; Amano, Eiichiro; Kawabata, Akifumi; Takeda, Akira
Journal of Organic Chemistry, 1980 , vol. 45, # 1 p. 43 - 47
反应条件
in toluene T=80°C; 24 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 17 p. 3186 - 3201
反应条件
1: 1) Na / 1. benzene, reflux, 8 h; 2. 2h at 0 deg C, then 6 h room temp. 2: 52 percent / 1 h / 300 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 1 p. 43 - 47
参考文献
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 241, p. 602
反应条件
1: Na / ethanol 2: aq. HCl View Scheme
参考文献
Ansell,M.F. et al.
Journal of the Chemical Society [Section] C: Organic, 1969 , p. 141 - 145
