N-叔丁氧羰基-N'-苄氧羰基-L-鸟氨酸合成路线 （共 23 条）
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=23°C; 24 h;
参考文献
Feldman
Tetrahedron Letters, 1991 , vol. 32, # 7 p. 875 - 878
反应条件
1.1: CuCO3 / H2O / 0.5 h 1.2: NaOH / H2O / 1 h 1.3: 88 percent / EDTA; aq. HCl / 2 h 2.1: 71 percent / aq. NaOH / tetrahydrofuran / 12 h View Scheme
参考文献
Chemical Communications, , # 8 p. 717 - 718
反应条件
1.1: CuCO3 / H2O / 0.5 h 1.2: NaOH / H2O / 1 h 1.3: 88 percent / EDTA; aq. HCl / 2 h 2.1: 71 percent / aq. NaOH / tetrahydrofuran / 12 h View Scheme
参考文献
Chemical Communications, , # 8 p. 717 - 718
反应条件
triethylamine in tert-butyl alcohol
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 2632 - 2636
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 38, p. 50 - 56
反应条件
1: 100 percent / H2, AcOH / Pd/C / methanol; H2O / 1810.02 - 2585.7 Torr 2: 80 percent / EDC, HOBt, NMM / acetonitrile / Ambient temperature View Scheme
参考文献
Semple; Rowley; Brunck; Ha-Uong; Minami; Owens; Tamura; Goldman; Siev; Ardecky; Carpenter; Ge; Richard; Nolan; Hakanson; Tulinsky; Nutt; Ripka
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4531 - 4536
反应条件
1: tert-butyl alcohol; dichloromethane / 24 h / 50 °C / |Inert atmosphere 2: hydrogen; water; hydrogenchloride; 5 Pd/C / ethanol / 24 h 3: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 18 h / 120 °C / |Inert atmosphere View Scheme
参考文献
Rosenberg, Adam J.; Clark, Daniel A.
Organic Letters, 2012 , vol. 14, # 17 p. 4678 - 4681
反应条件
1: With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran T=-15°C; 0.0166667 h; 2: With sodium tetrahydroborate; water in tetrahydrofuran T=-15°C; 0.166667 h;
参考文献
Martin, Olivier R.; Zhou, Wei; Wu, Xinfu; Front-Deschamps, Sophie; Moutel, Stephane; Schindl, Katharina; Jeandet, Patricia; Zbaeren, Claude; Bauer, Jacques A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 20 p. 6000 - 6014
反应条件
1: (S)-N5-(benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-ornithine; chloroformic acid ethyl ester With 4-methyl-morpholine in tetrahydrofuran T=-15°C; 0.5 h; 2: (S)-2-carbomethoxypyrrolidine hydrochloride With 4-methyl-morpholine in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 6 h; 3: With trifluoroacetic acid 0.25 h; Title compound not separated from byproducts;
参考文献
Reid, Robert C.; Abbenante, Giovanni; Taylor, Stephen M.; Fairlie, David P.
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4464 - 4471
反应条件
Multistep reaction. Title compound not separated from byproducts;
参考文献
Reid, Robert C.; Abbenante, Giovanni; Taylor, Stephen M.; Fairlie, David P.
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4464 - 4471
