2-(二环己基膦基)联苯合成路线 （共 10 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; Cl2Ni(1,2-bis(diphenylphosphino)ethane) in N,N-dimethyl-formamide T=100°C; 18.67 h; Product distribution / selectivity;
参考文献
Nippon Chemical Industrial Co., Ltd.
Patent: US2009/54690 A1, 2009 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: 1-bromo-2-phenylbenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 0.75 h; 2: chloro-dicyclohexylphosphine in tetrahydrofuran; hexane T=-78 - 0°C; Condensation; 14 h;
参考文献
Wolfe, John P.; Singer, Robert A.; Yang, Bryant H.; Buchwald, Stephen L.
Journal of the American Chemical Society, 1999 , vol. 121, # 41 p. 9550 - 9561
反应条件
in toluene T=100°C; Inert atmosphere;
参考文献
Van Overschelde, Michel; Vervecken, Elias; Modha, Sachin G.; Cogen, Simon; Van der Eycken, Erik; Van der Eycken, Johan
Tetrahedron, 2009 , vol. 65, # 32 p. 6410 - 6415
反应条件
1.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; ethylene glycol dimethyl ether / 5 h / 80 °C / |Inert atmosphere 2.1: n-butyllithium / hexane; diethyl ether / 2 h / 0 °C 2.2: 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 15, # 24 p. 6186 - 6189
反应条件
1.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; ethylene glycol dimethyl ether / 5 h / 80 °C / |Inert atmosphere 2.1: n-butyllithium / hexane; diethyl ether / 2 h / 0 °C 2.2: 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 15, # 24 p. 6186 - 6189
反应条件
1: 1-bromo-2-phenylbenzene With n-butyllithium in diethyl ether; hexane T=0°C; 2 h; 2: Cy2P-Hal in diethyl ether; hexane T=20°C; 1 h;
参考文献
Chemical Communications, , vol. 50, # 17 p. 2193 - 2195
反应条件
Inert atmosphereReflux;
参考文献
Van Overschelde, Michel; Vervecken, Elias; Modha, Sachin G.; Cogen, Simon; Van der Eycken, Erik; Van der Eycken, Johan
Tetrahedron, 2009 , vol. 65, # 32 p. 6410 - 6415
反应条件
1: hydrogen tetrachloroaurate(III) tetrahydrate With di-n-propyl sulfide in ethanol
T=40°C; 0.166667 h;
2: 2-dicyclohexylphosphino-1,1'-biphenyl in ethanol
T=40°C; 1 h;
参考文献
Zalesskiy, Sergey S.; Sedykh, Alexander E.; Kashin, Alexey S.; Ananikov, Valentine P.
Journal of the American Chemical Society, 2013 , vol. 135, # 9 p. 3550 - 3559
反应条件
in dichloromethane
1.75 h;
参考文献
Hashmi, A. Stephen K.; Bechem, Benjamin; Loos, Annette; Hamzic, Melissa; Rominger, Frank; Rabaa, Hassan
Australian Journal of Chemistry, 2014 , vol. 67, # 3 p. 481 - 499
反应条件
palladium diacetate in ethylene glycol dimethyl ether
参考文献
Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus
Patent: US2002/45615 A1, 2002 ;
