4-[二(环己基氨基)亚甲基]吗啉-4-鎓5'-O-(4-吗啉基磷酸基)腺苷合成路线 （共 8 条）
反应条件
in ethyl acetate; tert-butyl alcohol Heating;
参考文献
Millo, Enrico; Zocchi, Elena; Galatini, Andrea; Benatti, Umberto; Damonte, Gianluca
Synthetic Communications, 2008 , vol. 38, # 19 p. 3260 - 3269
反应条件
magnesium sulfate; manganese (II) chloride in formamide 16 h; Ambient temperature;
参考文献
Lee, Jaemoon; Churchil, Hywyn; Choi, Woo-Baeg; Lynch, Joseph E.; Roberts; Volante; Reider, Paul J.
Chemical Communications, 1999 , # 8 p. 729 - 730
反应条件
1: N,N'-dicyclohexyl-4-morpholinecarboxamidinium salt of adenosine-5'-phosphoromorpholidate; dTMP disodium salt With 1H-tetrazole; MgCl2*6H2O; water T=20°C; 1.5 h; in ball mill; 2: triethylammonium bicarbonate in water; acetonitrile pH=8.2;
参考文献
Ravalico, Francesco; Messina, Ivano; Berberian, M. Victoria; James, Stuart L.; Migaud, Marie E.; Vyle, Joseph S.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 19 p. 6496 - 6497
反应条件
1: [3H]-NMN; N,N'-dicyclohexyl-4-morpholinecarboxamidinium salt of adenosine-5'-phosphoromorpholidate With 1H-tetrazole; MgCl2*6H2O; water T=20°C; 1.5 h; in ball mill; 2: triethylammonium bicarbonate in water; acetonitrile pH=8.2;
参考文献
Ravalico, Francesco; Messina, Ivano; Berberian, M. Victoria; James, Stuart L.; Migaud, Marie E.; Vyle, Joseph S.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 19 p. 6496 - 6497
反应条件
1: N,N'-dicyclohexyl-4-morpholinecarboxamidinium salt of adenosine-5'-phosphoromorpholidate; ADP*H1.6*Na1.4 With 1H-tetrazole; MgCl2*6H2O; water T=20°C; 1.5 h; in ball mill; 2: triethylammonium bicarbonate in water; acetonitrile pH=8.2;
参考文献
Ravalico, Francesco; Messina, Ivano; Berberian, M. Victoria; James, Stuart L.; Migaud, Marie E.; Vyle, Joseph S.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 19 p. 6496 - 6497
反应条件
1: N,N'-dicyclohexyl-4-morpholinecarboxamidinium salt of adenosine-5'-phosphoromorpholidate; ATP disodium salt With 1H-tetrazole; MgCl2*6H2O; water T=20°C; 1.5 h; in ball mill; 2: triethylammonium bicarbonate in water; acetonitrile pH=8.2;
参考文献
Ravalico, Francesco; Messina, Ivano; Berberian, M. Victoria; James, Stuart L.; Migaud, Marie E.; Vyle, Joseph S.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 19 p. 6496 - 6497
反应条件
1: ribose-5-monophosphate barium salt; N,N'-dicyclohexyl-4-morpholinecarboxamidinium salt of adenosine-5'-phosphoromorpholidate With 1H-tetrazole; MgCl2*6H2O; water T=20°C; 1.5 h; in ball mill; 2: triethylammonium bicarbonate in water; acetonitrile pH=8.2;
参考文献
Ravalico, Francesco; Messina, Ivano; Berberian, M. Victoria; James, Stuart L.; Migaud, Marie E.; Vyle, Joseph S.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 19 p. 6496 - 6497
反应条件
pyridine
T=45°C; 5 h;
参考文献
Gebeyehu; Marquez; Kelley; Cooney; Jayaram; Johns
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 922 - 925
