4-羟基-3-甲氧基-2-硝基苯甲醛合成路线 （共 31 条）
反应条件
potassium carbonate in methanol T=20°C; 2 h; Acidic aqueous solution;
参考文献
Bayer Healthcare AG
Patent: WO2004/29055 A1, 2004 ;
Location in patent: Page 51 ;
WO 2004/029055 A1
反应条件
1: With nitric acid T=-10 - 5°C; 2: With water; sodium hydroxide Heating;
参考文献
Nimgirawath, Surachai; Udomputtimekakul, Phansuang; Taechowisan, Thongchai; Wanbanjob, Asawin; Shen, Yuemao
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 4 p. 368 - 376
反应条件
nitrogen(IV) oxide P=225.02 Torr; 12 h;
参考文献
Journal of Organic Chemistry, , vol. 60, # 17 p. 5494 - 5503
反应条件
nitric acid in acetic anhydride
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 24 p. 6553 - 6557
反应条件
nitric acid T=2 - 6°C; 0.25 h;
参考文献
Journal of Chemical Research, Miniprint, , # 1 p. 316 - 363
反应条件
sodium hydroxide; water in ethanol 0.5 h; Reflux;
参考文献
Journal of Fluorine Chemistry, , vol. 130, # 2 p. 216 - 224
反应条件
T=2 - 6°C; Nitrierung,und folgende Verseifung mit Kalilauge;
参考文献
Journal of the American Chemical Society, , vol. 50, p. 2561
反应条件
hydrogenchloride; nitric acid 1.) 2 deg C - 6 deg C, 15 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Chemical Research, Miniprint, , # 1 p. 316 - 363
反应条件
1: NO2/HNO3 / acetic acid 2: Al(OiPr)3 / propan-2-ol 3: (i) H2, aq. HCl, Pd-C, (ii) aq. FeCl3 4: K2CO3 / acetone 5: aq. Na2S2O3 / diethyl ether View Scheme
参考文献
Koshi,K.; Shimizu,M.
Chemical and Pharmaceutical Bulletin, 1968 , vol. 16, p. 2343 - 2350
反应条件
1: NO2/HNO3 / acetic acid 2: Al(OiPr)3 / propan-2-ol 3: (i) H2, aq. HCl, Pd-C, (ii) aq. FeCl3 4: K2CO3 / acetone View Scheme
参考文献
Koshi,K.; Shimizu,M.
Chemical and Pharmaceutical Bulletin, 1968 , vol. 16, p. 2343 - 2350
