5H-吡嗪并[2,3-b]吲哚合成路线 （共 13 条）
反应条件
methanol in ethyl acetate
T=20°C; 144 h;
参考文献
Alphonse, France-Aimee; Routier, Sylvain; Coudert, Gerard; Merour, Jean-Yves
Heterocycles, 2001 , vol. 55, # 5 p. 925 - 940
反应条件
triethylamine; tetrakis(triphenylphosphine) palladium(0)
T=65°C; Condensation; 0.666667 h;
参考文献
Malapel-Andrieu, Beatrice; Merour, Jean-Yves
Tetrahedron, 1998 , vol. 54, # 37 p. 11095 - 11110
反应条件
acetic acid in ethanol
参考文献
Capdevielle, Patrice; Maumy, Michel
Tetrahedron Letters, 1993 , vol. 34, # 18 p. 2953 - 2956
反应条件
in diphenylether
T=220°C; 24 h;
参考文献
Bergman, Jan; Vallberg, Hans
Acta Chemica Scandinavica, 1997 , vol. 51, # 6-7 p. 742 - 752
反应条件
in 1,4-dioxane
T=20°C; 5 h;
参考文献
Alphonse, France-Aimee; Routier, Sylvain; Coudert, Gerard; Merour, Jean-Yves
Heterocycles, 2001 , vol. 55, # 5 p. 925 - 940
反应条件
1.1: tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane / 0.33 h / 20 °C
1.2: 53 percent / Na2CO3 / 1,2-dimethoxy-ethane / 8 h / Heating
2.1: 50 percent / sulfuric acid / H2O / 3 h / Heating
3.1: hydrochloric acid; NaNO2 / H2O / 1.5 h / 0 - 5 °C
3.2: 97 percent / sodium azide; sodium acetate trihydrate / H2O / 1 h / 0 - 5 °C
4.1: 1,2-dichloro-benzene / 1 h / Heating
View Scheme
参考文献
Tapolcsanyi, Pal; Krajsovszky, Gabor; Ando, Romeo; Lipcsey, Peter; Horvath, Gyula; Matyus, Peter; Riedl, Zsuzsanna; Hajos, Gyoergy; Maes, Bert U. W.; Lemiere, Guy L. F.
Tetrahedron, 2002 , vol. 58, # 51 p. 10137 - 10143
反应条件
1: 96 percent / bromine / CH2Cl2 / 0.33 h / 20 °C
2: 10 percent / dioxane / 5 h / 20 °C
View Scheme
参考文献
Alphonse, France-Aimee; Routier, Sylvain; Coudert, Gerard; Merour, Jean-Yves
Heterocycles, 2001 , vol. 55, # 5 p. 925 - 940
反应条件
in 1,2-dichloro-benzene
1 h; Heating;
参考文献
Tapolcsanyi, Pal; Krajsovszky, Gabor; Ando, Romeo; Lipcsey, Peter; Horvath, Gyula; Matyus, Peter; Riedl, Zsuzsanna; Hajos, Gyoergy; Maes, Bert U. W.; Lemiere, Guy L. F.
Tetrahedron, 2002 , vol. 58, # 51 p. 10137 - 10143
反应条件
1: 72 percent / dioxane / 5 h / 20 °C
2: 80 percent / MeOH / ethyl acetate / 144 h / 20 °C
View Scheme
参考文献
Alphonse, France-Aimee; Routier, Sylvain; Coudert, Gerard; Merour, Jean-Yves
Heterocycles, 2001 , vol. 55, # 5 p. 925 - 940
反应条件
1: 3 h / Heating
2: ethanol / 5 deg C to rt
3: 97 percent / m-CPBA / methanol / Ambient temperature
4: 83 percent / KOH, H2O / ethanol / 4 h / Heating
5: 60 percent / diphenyl ether / 24 h / 220 °C
View Scheme
参考文献
Bergman, Jan; Vallberg, Hans
Acta Chemica Scandinavica, 1997 , vol. 51, # 6-7 p. 742 - 752
