N-2,3-二氢-1H-茚-2-基-n-甲基胺盐酸盐合成路线 (共 4 条)
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
Synthelabo
Patent: US5179108 A1, 1993 ;
US 5179108 A
反应条件
1: With triethylamine in tetrahydrofuran 1 h; 2: With lithium aluminium tetrahydride in tetrahydrofuran 3 h; Heating / reflux; 3: With sodium hydroxide; water more than 3 stages;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/821 A1, 2005 ;
Location in patent: Page 31 ;
WO 2005/000821 A1
反应条件
sodium tetrahydroborate in methanol; water 1 h;
参考文献
Fotsch; Sonnenberg; Chen; Hale; Karbon; Norman
Journal of Medicinal Chemistry, 2001 , vol. 44, # 14 p. 2344 - 2356
参考文献
Levin; Graham; Kolloff
Journal of Organic Chemistry, 1944 , vol. 9, p. 380,385