H-顺式-4-氟-脯氨酸合成路线 （共 12 条）
反应条件
water in isopropyl alcohol Ambient temperature;
参考文献
Burger, Klaus; Rudolph, Martin; Fehn, Susanna; Sewald, Norbert
Journal of Fluorine Chemistry, 1994 , vol. 66, # 1 p. 87 - 90
反应条件
1: 38 percent / diethylaminosulfur trifluoride / CH2Cl2 / 20 h / 0 - 20 °C 2: 22 percent / water / propan-2-ol / 48 h / 20 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # 12 p. 1135 - 1144
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 76 percent / Et3N / CHCl3 / 0 °C 2: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 3: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. 4: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 5: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 2: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. 3: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 4: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 2: TFA / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: dimethylsulfoxide / 20 - 50 °C 2: 38 percent / diethylaminosulfur trifluoride / CH2Cl2 / 20 h / 0 - 20 °C 3: 22 percent / water / propan-2-ol / 48 h / 20 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # 12 p. 1135 - 1144
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=0 - 20°C; 9 h;
参考文献
Loenarz, Christoph; Mecinovic, Jasmin; Chowdhury, Rasheduzzaman; McNeill, Luke A.; Flashman, Emily; Schofield, Christopher J.
Angewandte Chemie - International Edition, 2009 , vol. 48, # 10 p. 1784 - 1787
反应条件
triethylamine in methanol Yield given;
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=0 - 20°C; 9 h;
参考文献
Angewandte Chemie - International Edition, , vol. 48, # 10 p. 1784 - 1787
