N,N-二乙基-2-溴乙酰胺合成路线 （共 21 条）
反应条件
in dichloromethane T=-60 - 20°C; 1 h;
参考文献
Riches, Samantha L.; Saha, Chandreyee; Filgueira, Noelia Fontan; Grange, Emma; McGarrigle, Eoghan M.; Aggarwal, Varinder K.
Journal of the American Chemical Society, 2010 , vol. 132, # 22 p. 7626 - 7630
反应条件
in tetrahydrofuran T=0 - 20°C; 1.5 h;
参考文献
ACTELION PHARMACEUTICALS LTD.
Patent: WO2004/33418 A2, 2004 ;
Location in patent: Page 64 ;
WO 2004/033418 A2
反应条件
in dichloromethane T=-60 - 20°C;
参考文献
Booysen; Holzapfel
Synthetic Communications, 1995 , vol. 25, # 10 p. 1461 - 1472
反应条件
monobromoacetic acid chloride in dichloromethane
参考文献
Journal of Organic Chemistry, , vol. 27, p. 4361 - 4365
反应条件
in dichloromethane T=-25 - 20°C; 3.5 h;
参考文献
Chemistry of Natural Compounds, , vol. 48, # 6 p. 1047 - 1053
Khim. Prir. Soedin., , vol. 48, # 6 p. 924 - 929,6
反应条件
dicyclohexyl-carbodiimide 1.) CH2Cl2, 0 deg C, 30 min, 2.) CH2Cl2, -10 deg C, 2 h then RT; Yield given. Multistep reaction;
参考文献
Bulletin de la Societe Chimique de France, , vol. 132, # 2 p. 166 - 177
反应条件
1: 3-(4-isopropoxyphenyl)-3-oxopropanenitrile With sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C; Inert atmosphere; 2: alpha-bromo-N,N-diethylacetamide in tetrahydrofuran; mineral oil T=0 - 20°C; Inert atmosphere; 3: With hydrazine hydrate; acetic acid in ethanol 13 h; Inert atmosphereReflux;
参考文献
Banister, Samuel D.; Wilkinson, Shane M.; Hanani, Raphy; Reynolds, Aaron J.; Hibbs, David E.; Kassiou, Michael
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3780 - 3783
反应条件
(i) NaH, DMF, (ii) /BRN= 1752322/; Multistep reaction;
参考文献
Islip; Closier; Neville
Journal of Medicinal Chemistry, 1974 , vol. 17, # 2 p. 207 - 209
反应条件
lithium diisopropyl amide in tetrahydrofuran 1.) -78 deg C to room temp., 1 h, 2.) room temp., 8 h;
参考文献
Li, Nan-Sheng; Deng, Min-Zhi; Huang, Yao-Zeng
Journal of Organic Chemistry, 1993 , vol. 58, # 22 p. 6118 - 6119
反应条件
diborane; lithium diisopropyl amide 1.) THF, room temp., 30 min, 2.) THF, -78 deg C, 30 min; room temp., 3 h; Yield given. Multistep reaction;
参考文献
Li, Nan-Sheng; Deng, Min-Zhi; Huang, Yao-Zeng
Journal of Organic Chemistry, 1993 , vol. 58, # 22 p. 6118 - 6119
