3-羧酸-4-羧酸甲酯吡啶合成路线 （共 21 条）
参考文献
Procopiou, Panayiotis A.; Browning, Christopher; Gore, Paul M.; Lynn, Sean M.; Richards, Stephen A.; Slack, Robert J.; Sollis, Steven L.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 20 p. 6097 - 6108
反应条件
hydrogenchloride in tetrahydrofuran; methanol; water 1.) from -70 deg C to RT, overnight, 2.) 0 deg C;
参考文献
Ketcha, Daniel M.; Gribble, Gordon W.
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5451 - 5457
反应条件
in tetrahydrofuran T=-70 - 20°C; 18 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/122156 A1, 2007 ;
Location in patent: Page/Page column 90-91 ;
WO 2007/122156 A1
反应条件
1: pyridine-3, 4-dicarboxylic acid With acetic anhydride T=100°C; 12 h; 2: methanol 16 h; Reflux;
参考文献
US2012/95022 A1, ;
Page/Page column 36-37 ;
反应条件
in dichloromethane 18 h; Ambient temperature;
参考文献
Praly-Deprez, Isabelle; Rivalle, Christian; Huel, Christiane; Belehradek, Jean; Paoletti, Claude; Bisagni, Emile
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 12 p. 3165 - 3171
反应条件
1: acetic anhydride / 1 h / Heating 2: 82 percent / CH2Cl2 / 18 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 12 p. 3165 - 3171
反应条件
sodium hydroxide; water T=20°C; 1.5 h; Yields of byproduct given;
参考文献
Ashcroft, William R.; Beal, Michael G.; Joule, John A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 3012 - 3015
参考文献
Koermendy, K.; Kovacs, T.; Ruff, F.; Koevesdi, I.
Acta Chimica Hungarica, 1983 , vol. 112, # 4 p. 487 - 500
参考文献
Monatshefte fuer Chemie, , vol. 21, p. 963
Monatshefte fuer Chemie, , vol. 23, p. 935
参考文献
Monatshefte fuer Chemie, , vol. 21, p. 963
Monatshefte fuer Chemie, , vol. 23, p. 935
