2,2,2-三氟-1-(4-硝基苯基)乙醇合成路线 （共 7 条）
反应条件
1: With tetrabutyl ammonium fluoride in tetrahydrofuran T=25°C; 1 h; 2: With hydrogenchloride in water 3 h;
参考文献
THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
Patent: EP1367046 A1, 2003 ;
Location in patent: Page 27 ;
EP 1367046 A1
反应条件
1: in N,N-dimethyl-formamide T=50°C; 1 h; Inert atmosphere; 2: With hydrogenchloride in water; N,N-dimethyl-formamide T=20°C;
参考文献
Levin, Vitalij V.; Dilman, Alexander D.; Belyakov, Pavel A.; Struchkova, Marina I.; Tartakovsky, Vladimir A.
Tetrahedron Letters, 2011 , vol. 52, # 2 p. 281 - 284
反应条件
1-tert-butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)-phosphoranylidenamino]-2Λ54Λ5-catenadi(phosphazene) in tetrahydrofuran; hexane T=-30°C; 2 h; Schlenk techniqueInert atmosphere;
参考文献
Kawai, Hiroyuki; Yuan, Zhe; Tokunaga, Etsuko; Shibata, Norio
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 9 p. 1446 - 1450
反应条件
magnesium; mercury dichloride in N,N-dimethyl-formamide T=-15 - 20°C;
参考文献
Zhao, Yanchuan; Zhu, Jieming; Ni, Chuanfa; Hu, Jinbo
Synthesis, 2010 , # 11 art. no. C00810SS, p. 1899 - 1904
反应条件
1: potassium fluoride; triphenyltin fluoride; n-Bu3MeN(+)HSO4(-) / CH2Cl2 / 1 h / 0 - 20 °C 2: HCl / H2O / 0.25 h View Scheme
参考文献
Sanhueza, Italo A.; Bonney, Karl J.; Nielsen, Mads C.; Schoenebeck, Franziska
Journal of Organic Chemistry, 2013 , vol. 78, # 15 p. 7749 - 7753
反应条件
Oxonereg;; sodium 2-iodobenzenesulfonate in acetonitrile
T=90°C; 18 h;
参考文献
Tanaka, Yusuke; Ishihara, Takashi; Konno, Tsutomu
Journal of Fluorine Chemistry, 2012 , vol. 137, p. 99 - 104
反应条件
2,6-dimethylpyridine; oxoammonium salt in dichloromethane
T=20°C; Sealed tube;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
