3-甲基1H-吡咯-2-甲醛合成路线 （共 8 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0°C; Vilsmeier Reaction; Inert atmosphere; 2: 3-methyl pyrrole in dichloromethane T=20°C; 10 h; Inert atmosphere; 3: With sodium hydroxide in water T=20°C; 1 h;
参考文献
Stierle, Donald B.; Faulkner, John D.
Journal of Organic Chemistry, 1980 , vol. 45, # 24 p. 4980 - 4982
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0°C; 0.25 h; 2: 3-methyl pyrrole in 1,2-dichloro-ethane T=0°C; 0.25 h; Heating / reflux; 3: With sodium acetate in water; 1,2-dichloro-ethane T=0°C; 0.333333 h; Heating / reflux;
参考文献
Bristol Myers Squibb Company
Patent: US6982265 B1, 2006 ;
Location in patent: Page/Page column 22-23 ;
反应条件
copper(II) sulfate in water 6 h; Irradiation;
参考文献
Campbell, Shirley E.; Comer, Murray C.; Derbyshire, Paul A.; Despinoy, Xavier L. M.; McNab, Hamish; Morrison, Roderick; Sommerville, Craig C.; Thornley, Craig
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 15 p. 2195 - 2202
反应条件
potassium hydroxide in water; tert-butyl alcohol T=60°C; 15 h;
参考文献
Smith, Kevin M.; Bobe, Frank W.; Minnetian, Ohannes M.; Hope, Hakon; Yanuck, Michael D.
Journal of Organic Chemistry, 1985 , vol. 50, # 6 p. 790 - 792
反应条件
1: aqueous-alcoholic KOH-solution 2: 190 - 200 °C View Scheme
参考文献
Fischer; Wiedemann
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1926 , vol. 155, p. 61
反应条件
N-methylamine hydrochloride; potassium acetate in methanol
T=18°C; 25 h;
参考文献
Dutton, Christopher J.; Fookes, Christopher J. R.; Battersby, Alan R.
Journal of the Chemical Society, Chemical Communications, 1983 , # 21 p. 1237 - 1238
反应条件
1: 88 percent
2: 90 percent / borohydride
View Scheme
参考文献
Battersby, Alan R.; Dutton, Christopher J.; Fookes, Christopher J. R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 1569 - 1576
反应条件
1: 67.5 percent / Et3N / toluene / 4 h / Heating
2: 59.5 percent / POCl3, aq. AcONa / 1,2-dichloro-ethane / 1.) reflux, 0.5 h, 2.) reflux, 1 h
3: 39 percent / aq. KOH / methanol / 0.67 h / Heating
View Scheme
参考文献
Boudif, Arezki; Momenteau, Michel
Journal of the Chemical Society. Perkin Transactions 2, 1996 , vol. 1996, # 11 p. 1235 - 1242
