1: 3-methoxybromobenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.333333 h;
2: N-methoxy-N-methyl-2-phenylacetamide in tetrahydrofuran; hexane
Further stages.;
参考文献
Moreno, Isabel; Tellitu, Imanol; Dominguez, Esther; SanMartin, Raul
European Journal of Organic Chemistry, 2002 , # 13 p. 2126 - 2135
1.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 - 0 °C
1.2: 2 h / 0 °C
2.1: pyridine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 16 h / 25 °C
View Scheme
参考文献
Patterson, Stephen; Alphey, Magnus S.; Jones, Deuan C.; Shanks, Emma J.; Street, Ian P.; Frearson, Julie A.; Wyatt, Paul G.; Gilbert, Ian H.; Fairlamb, Alan H.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6514 - 6530
1: 3-methoxybromobenzene With n-butyllithium in diethyl ether; hexane
T=-78 - 0°C; 2 h;
2: 2-amino-5-chloro-benzoic acid in tetrahydrofuran; diethyl ether; hexane
T=0°C; 2 h; Further stages;
参考文献
Patterson, Stephen; Alphey, Magnus S.; Jones, Deuan C.; Shanks, Emma J.; Street, Ian P.; Frearson, Julie A.; Wyatt, Paul G.; Gilbert, Ian H.; Fairlamb, Alan H.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6514 - 6530
